2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. Interleukin Related STAT
  4. SMI-10B13

SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models.

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SMI-10B13

SMI-10B13 Chemical Structure

CAS No. : 2502294-68-8

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SMI-10B13 Related Antibodies

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Description

SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models[1].

In Vitro

SMI-10B13 (100 μM) almost completely inhibits the ability of gp130 to bind to immobilized OSM[1].
SMI-10B13 (10 μM, 30 mins) reduces OSM-mediated pSTAT3 levels in T47D breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMI-10B13 Related Antibodies
In Vivo

SMI-10B13 (50 mg/kg, i.p., 12 h before tumor cell injection) inhibits tumor growth and prolongs survival in human breast cancer xenograft mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ER+ breast cancer xenograft mice models (7-8 weeks, athymic nu/nu mice)[1]
Dosage: 50 mg/kg
Administration: Intraperitoneally injection, 12 h before tumor cell injection and 3 times q week thereafter
Result: Showed a significant reduction in tumor growth.
Displayed minimal to no cytotoxicity at high concentrations.
Prevented metastasis and increased survival.
Molecular Weight

368.38

Formula

C23H16N2O3
CAS No.
SMILES

O=C(/C=C/C1=CC(C2=CC3=C(C=C2)C=CN3)=C(O1)C4=CC=C5C=CNC5=C4)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMI-10B13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMI-10B132502294-68-8Interleukin RelatedSTATILOncostatin MSTAT3T47DMCF-7Breast cancerInhibitorinhibitorinhibit

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