2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Interleukin Related Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Apoptosis
  4. Monotropein

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury.

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Monotropein Chemical Structure

Monotropein Chemical Structure

CAS No. : 5945-50-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 1 publication(s) in Google Scholar

Other Forms of Monotropein:

Monotropein Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Monotropein

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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HO-1 HO-2

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury[1][2][3].

In Vitro

Monotropein (100 μg/mL, 24 h) decreases the apoptotic rate of chondrocytes[1].
Monotropein (25-100 μg/mL, 24 h) significantly decreases the mRNA levels of MMP-3 and MMP-13 in chondrocytes[1].
Monotropein (25-100 μg/mL, 48 h) exhibits anti-apoptosis and anti-catabolic activity and counteracts the effect of IL-1β[1].
Monotropein (Compound Mon) (0-200 μg/mL, 24 h) enhances cell viability and reduces apoptosis in LPS-treated MLE-12 cells[3].
Monotropein (12.5-100 μg/mL, 24 h) reduces inflammatory response and fibrosis induced by LPS in MLE-12 cells[3].
Monotropein (100 μg/mL, 24 h) inhibits NF-κB pathway in LPS-elicited MLE-12 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Monotropein Related Antibodies

Western Blot Analysis[3]

Cell Line: LPS-elicited MLE-12 cells
Concentration: 100 μg/mL
Incubation Time: 24 h
Result: Decreased the concentrations of TNF-α, IL-1β, and IL-6.
Decreased relative protein expression of -SMA, FN, and Collagen I.
In Vivo

Monotropein (25-100 mg/kg, i.g., single dose) greatly reduces the content of IL-1β, TNF-α, and PGE2 in rat model with knee OA SF lavages[1].
Monotropein (100 mg/kg, i.g., single dose) exhibits chondroprotective effects on knee joint tissue of OA rat model[1].
Monotropein (20 mg/kg, i.p., 1 h pre-treatment and 24-48 h after) attenuates cisplatin-induced renal dysfunction and histopathological damage in AKI mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AKI BALB/c mouse model (20-25 g) injected (i.p.) with 20 mg/kg Cisplatin[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.), 1 h pre-treatment and 24-48 h after
Result: Reduced the level on BUN compared to control group.
Attenuated cisplatin-induced oxidative stress in kidney.
Attenuated inflammation in kidney.
Reversed the anti-apoptotic protein Bcl-2 and pro-apoptotic proteins including Bax.
Molecular Weight

390.34

Formula

C16H22O11
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@]3(O)CO)([H])[C@@](C=C3)([H])C(C(O)=O)=CO2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 31.25 mg/mL (80.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5619 mL 12.8093 mL 25.6187 mL
5 mM 0.5124 mL 2.5619 mL 5.1237 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.09%

SDS (393 KB)

COA (258 KB) HNMR (278 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5619 mL 12.8093 mL 25.6187 mL 64.0467 mL
5 mM 0.5124 mL 2.5619 mL 5.1237 mL 12.8093 mL
10 mM 0.2562 mL 1.2809 mL 2.5619 mL 6.4047 mL
15 mM 0.1708 mL 0.8540 mL 1.7079 mL 4.2698 mL
20 mM 0.1281 mL 0.6405 mL 1.2809 mL 3.2023 mL
25 mM 0.1025 mL 0.5124 mL 1.0247 mL 2.5619 mL
30 mM 0.0854 mL 0.4270 mL 0.8540 mL 2.1349 mL
40 mM 0.0640 mL 0.3202 mL 0.6405 mL 1.6012 mL
50 mM 0.0512 mL 0.2562 mL 0.5124 mL 1.2809 mL
60 mM 0.0427 mL 0.2135 mL 0.4270 mL 1.0674 mL
80 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8006 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Monotropein Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monotropein5945-50-6Interleukin RelatedKeap1-Nrf2Heme Oxygenase (HO)NF-κBApoptosisILHeme OxygenaseNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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