2. NF-κB Immunology/Inflammation Apoptosis MAPK/ERK Pathway Stem Cell/Wnt Neuronal Signaling Membrane Transporter/Ion Channel
  3. NF-κB COX Apoptosis ERK Calcium Channel
  4. Recoflavone

Recoflavone  (Synonyms: DA-6034 free acid)

Cat. No.: HY-106449 Purity: ≥98.0%
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Handling Instructions Technical Support

Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury.

For research use only. We do not sell to patients.

Recoflavone Chemical Structure

Recoflavone Chemical Structure

CAS No. : 203191-10-0

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Recoflavone Related Antibodies

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All COX Isoform Specific Products:

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COX COX-1 COX-2 COX-3

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury[1][2][3][4].

In Vitro

Recoflavone (100-250 µM; 24-48 h) increases mucin-like glycoprotein secretion in human corneal epithelial cells[1].
Recoflavone (200 µM; 24 h) significantly increases the production of several mucins including MUC1, MUC2, MUC4, MUC5AC, MUC5B and MUC16 in human conjunctival epithelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Recoflavone Related Antibodies
In Vivo

Recoflavone (3%; eye drops; single dose) significantly reduces corneal damage in a rabbit dry eye disease model[1].
Recoflavone (30 mg/kg; oral administration; once every 12 hours; 3 days) exhibits protective effects in a rat small intestinal injury model[2].
Recoflavone (30 mg/kg; oral gavage; twice daily; from day 7 to day 63) shows improvement effects in a mouse colitis-associated cancer model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male New Zealand White rabbits (2.5 kg) with desiccation-induced dry eye by keeping eyes open with a specula for 2 h[1]
Dosage: 3 %
Administration: Eye drops; single dose
Result: Significantly decreased methylene blue permeability in the cornea compared to the vehicle-treated group, indicating prevention of desiccation-induced corneal damage.
Animal Model: Sprague-Dawley rats aged 6 weeks old (250 g) treated Indomethacin (HY-14397) to induce small intestinal injury[2]
Dosage: 30 mg/kg
Administration: Oral administration; once every 12 hours; 3 days
Result: Increased the ERK expression.
Had significantly lower intestinal permeability compared with the control group, while the inflammation scores and the extent of hemorrhagic lesions showed no statistically significant differences.
Animal Model: C57BL/6 mice aged 10 weeks old (18-21 g) treated AOM (HY-111375) and DSS (HY-116282C) to induce colitis-associated cancer[3]
Dosage: 30 mg/kg
Administration: Oral gavage; twice daily; from day 7 to day 63
Result: Reduced the number of colon tumors.
Ameliorated weight loss and colon shortening.
Enhanced apoptosis , and inhibited the expression of proliferation marker Ki-67, COX-2, and phospho-IKKα in colon tissue.
Molecular Weight

386.35

Formula

C20H18O8
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=C2C(OC(C3=CC(OC)=C(OC)C=C3)=CC2=O)=CC(OCC(O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (103.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5883 mL 12.9416 mL 25.8833 mL
5 mM 0.5177 mL 2.5883 mL 5.1767 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5883 mL 12.9416 mL 25.8833 mL 64.7082 mL
5 mM 0.5177 mL 2.5883 mL 5.1767 mL 12.9416 mL
10 mM 0.2588 mL 1.2942 mL 2.5883 mL 6.4708 mL
15 mM 0.1726 mL 0.8628 mL 1.7256 mL 4.3139 mL
20 mM 0.1294 mL 0.6471 mL 1.2942 mL 3.2354 mL
25 mM 0.1035 mL 0.5177 mL 1.0353 mL 2.5883 mL
30 mM 0.0863 mL 0.4314 mL 0.8628 mL 2.1569 mL
40 mM 0.0647 mL 0.3235 mL 0.6471 mL 1.6177 mL
50 mM 0.0518 mL 0.2588 mL 0.5177 mL 1.2942 mL
60 mM 0.0431 mL 0.2157 mL 0.4314 mL 1.0785 mL
80 mM 0.0324 mL 0.1618 mL 0.3235 mL 0.8089 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6471 mL
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Recoflavone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Recoflavone203191-10-0DA-6034DA6034DA 6034NF-κBCOXApoptosisERKCalcium ChannelNuclear factor-κBNuclear factor-kappaBCyclooxygenaseExtracellular signal regulated kinasesCa2+ channelsCa channelsdry eye disease modelsmall intestinal injury modecolitis-associated cancer modelhuman corneal epithelial cellshuman conjunctival epithelial cellsInhibitorinhibitorinhibit

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