2. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Monoamine Oxidase Reactive Oxygen Species (ROS)
  4. MAO-B-IN-49

MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750)-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD.

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MAO-B-IN-49

MAO-B-IN-49 Chemical Structure

CAS No. : 3098883-91-8

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MAO-B-IN-49 Related Antibodies

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Description

MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750)-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD[1].

In Vitro

MAO-B-IN-49 (Compound ZM24) (2-50 μM, 24 h) demonstrates cell viability exceeding 75 % across all tested conditions in HT22 cells[1].
MAO-B-IN-49 (5-20 μM, 24 h) is co-incubated with cells at different concentrations, and Lipopolysaccharides (HY-D1056) (LPS)-induced ROS production is significantly reduced in HT22 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-49 Related Antibodies

Cell Viability Assay

Cell Line: HT22 hippocampal neuronal cell line
Concentration: 2 μM, 5 μM, 10 μM, 20μM, 50 μM
Incubation Time: 24 h
Result: Demonstrates cell viability exceeding 75 % across all tested conditions.
In Vivo

MAO-B-IN-49 (10 mg/kg, 30 mg/kg, I.p., once daily for 7 days) significantly improves MPTP-induced motor dysfunction (including motor activity, coordination, and muscle strength) in Parkinson's disease model mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A Parkinson's disease model was induced in male C57BL/6J mice (2 months old, weighing 20±2 g) by injection of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)[1].
Dosage: 10 mg/kg, 30 mg/kg
Administration: I.p., 30 mins before MPTP, once daily for 7 days
Result: Led to a near-normal restoration of movement patterns, indicating a significant improvement in motor function.
Significantly improved the movement disorder in mice.
Effectively relieved forelimb muscle weakness in mice.
Molecular Weight

362.37

Formula

C19H20F2N2O3
CAS No.
SMILES

C[C@H](N1CCOC2=C(C1)C=CC(OCC3=CC(F)=C(C=C3)F)=C2)C(N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-49 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-493098883-91-8Monoamine OxidaseReactive Oxygen Species (ROS)MAOIsoform selectivityStructure activity relationshiphMAO-BParkinson’s diseasePDInhibitorinhibitorinhibit

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