PSMA-DIM 

PSMA-DIM is a dimeric PSMA ligand with a K_d of 37.09 nM for LNCaP cells. PSMA-DIM can be radiolabeled with [⁶⁸Ga]Ga to form [⁶⁸Ga]Ga-PSMA-DIM. [⁶⁸Ga]Ga-PSMA-DIM can effectively distinguish between cells and animal models with different expression levels of PSMA. [⁶⁸Ga]Ga-PSMA-DIM exhibits high LNCaP cells uptake and tumor uptake peak values. PSMA-DIM can be used for the study of prostate cancer (PCa)^[1].

[⁶⁸Ga]Ga-PSMA-DIM (1.58 nM, 15-120 min) has higher internalization capacity for LNCaP cells than 22Rv1 and PC-3 cells and its dependent on the PSMA expression level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[⁶⁸Ga]Ga-PSMA-DIM (5.55 MBq, i.v., single dose) shows great uptake in PSMA-positive LNCaP and 22Rv1 mice tumors, while minimal uptake in PC-3 tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2649.68

C₁₁₉H₁₇₄IN₂₁O₃₉

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Quan Xie, et al. Preclinical Evaluation Study of 68Ga-Labeled PSMA-Targeted Dimer Probe. pubs.acs.org. 2025 Jun 10.