2. Anti-infection Neuronal Signaling MAPK/ERK Pathway
  3. Fungal Calcineurin p38 MAPK
  4. Antifungal agent 18

Antifungal agent 18 is an antifungal agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes.

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Antifungal agent 18

Antifungal agent 18 Chemical Structure

CAS No. : 2572713-30-3

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Antifungal agent 18 Related Antibodies

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Description

Antifungal agent 18 is an antifungal agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes[1].

In Vitro

Antifungal agent 18 (compound 22h) (0.5-128 μg/mL) shows antifungal activities to C.neoformans (H99), C.albicans (SC5314), C.glabrata (BG2), and A.fumigatus (af293) with MICs of 1, 2, 4, and 4 μg/mL, espectively[1].
Antifungal agent 18 (0.5-12.5 μM, 24 h) shows no significant cytotoxicity in HEK293T and HaCaT cells[1].
Antifungal agent 18 (0-32 μg/mL, 24 h) is a fast-acting fungicidal drug against a broad spectrum of human fungal pathogens causing invasive or cutaneous infection[1].
Antifungal agent 18 (40 days) does not induce resistance in C.albicans and C.glabrata[1].
Antifungal agent 18 (0-8 μg/mL, 24 h) distorts the cellular morphology and reduces the cell wall and capsule thickness of C.neoformans, and causes cytoplasmic detachment from the cell membrane in C.albicans[1].
Antifungal agent 18 (0-8 μg/mL, 0-2 h) activates the Mpk1 pathway, and increases HXL1 activation levels to activate the UPR pathway[1].
Antifungal agent 18 (8 μg/mL, 90 min) induces nuclear translocation of Crz1 to activate the calcineurin pathway[1].
Antifungal agent 18 (0.1 %-5 % w/w, 24 h) shows superior antifungal activity in a T.rubrum-infected nail model in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 18 Related Antibodies

Western Blot Analysis[1]

Cell Line: C.neoformans WT cells and C.neoformans H99 cells
Concentration: 4 and 8 μg/mL
Incubation Time: 30, 60, 90 min, and 2 h
Result: Increased pMpk1 levels within 30 min, which peaked at 60 min and decreased after 90 min.
Increased the ratio of HXL1s/HXL1u in a dose-dependent manner.
In Vivo

Antifungal agent 18 (2 % w/w, topical application., 6, 24, and 48 h) shows antifungal activity in a C. albicans infection mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (7-week-old) subcutaneously injected with C.albicans cells[1]
Dosage: 2 % w/w
Administration: topical application., 6, 24, and 48 h
Result: Resulted in a marked reduction in the size of inflammation.
Resulted in a relatively softer epidermal stratum corneum and a more compact epidermal keratin layer compared to the vehicle group.
Molecular Weight

401.76

Formula

C19H23Cl3N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(CCC)C(NCCC1=CC=C(C2=CC(Cl)=C(Cl)C=C2)C=C1)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Antifungal agent 18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 182572713-30-3Antifungal agent18Antifungal agent-18FungalCalcineurinp38 MAPKPP2BPPP3antifungalbroad-spectrumcell wall integrityUPRcalcineurinMpk1MAPKinvasive fungal pathogenscutaneous dermatophytesC.neoformansC.albicansC.glabrataA.fumigatusT.rubrum-infected nail modelC.albicans Infection modelInhibitorinhibitorinhibit

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