2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage Immunology/Inflammation Metabolic Enzyme/Protease
  3. Ferroptosis Microtubule/Tubulin COX Glutathione Peroxidase
  4. Ferroptosis inducer-9

Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC50 of 14 nM and inhibits [3H]colchicine binding. Ferroptosis inducer-9 reduces expression of GPX4 and FTH, increases COX2 and ACSL4, lowers GSH, NADP+, and NADPH levels, increases LPO, MDA, and Fe(II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC).

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Ferroptosis inducer-9

Ferroptosis inducer-9 Chemical Structure

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Ferroptosis inducer-9 Related Antibodies

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Description

Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC50 of 14 nM and inhibits [3H]colchicine binding. Ferroptosis inducer-9 reduces expression of GPX4 and FTH, increases COX2 and ACSL4, lowers GSH, NADP+, and NADPH levels, increases LPO, MDA, and Fe(II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC)[1].

In Vitro

Ferroptosis inducer-9 (Compound 12) inhibits tubulin polymerization (IC50 = 550 nM) and MCF-7 cell growth (IC50 = 14 nM)[1].
Ferroptosis inducer-9 (0.3-1 μM) lead to total cell growth arrest and profound nuclear and cytoskeletal morphological alterations in H2BC11-moxGFP/sTagRFP-TUBA1B tagged MDA-MB-231 cells [1].
Ferroptosis inducer-9 (72 h) inhibits the growth of SW620, SW480, HCT116, HepG2 and CC-2509f cells with IC50 values of 0.633 μM, 0.0654 μM, 0.389 μM, 107.3μM, 52.9 μM, respectively[1].
Ferroptosis inducer-9 reduces the expression of ferroptosis inhibitory factors (SLC7A11, SLC3A2, SLC11A2, NRF2, NCOA4, KEAP1, GPX4, FTL, FTH1) and increases the expression of ferroptosis promoting factors (PTGS2, NOX1, COX2, COX4, ACSL4) in HCT116 cells[1].
Ferroptosis inducer-9 decreases GSH and SOD concentration, lowers NADP+ and NADPH concentrations, increases LPO, MDA, and Fe(II) levels and GSSG concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-9 Related Antibodies
In Vivo

Ferroptosis inducer-9 (Compound 12) (25 mg/kg, intraperitoneal injection, once every 2 days for 30 days) shows significant anti-tumor effects in nude mice bearing HCT116 colorectal cancer xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 colorectal cancer cells (1×108 cells/mL in logarithmic growth phase) were subcutaneously implanted into the flanks of 10-week-old male BALB/C mice[1]
Dosage: 25 mg/kg
Administration: intraperitoneal injection, once every 2 days for 30 days
Result: Achieved tumor growth inhibition.
Reduced the Ki67 expression.
Molecular Weight

410.44

Formula

C21H18N2O5S
SMILES

O=C(C1=CN(C2=NC=CS2)C=C1C3=CC=CO3)C4=CC(OC)=C(OC)C(OC)=C4
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Room temperature in continental US; may vary elsewhere.
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis inducer-9Ferroptosis inducer9Ferroptosis inducer 9FerroptosisMicrotubule/TubulinCOXGlutathione PeroxidaseCyclooxygenasebreast cancer (TNBC)colorectal cancer (CRC)MCF-7 cellscolchicine site tubulinferroptosisInhibitorinhibitorinhibit

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