2. Immunology/Inflammation
  3. TREM receptor
  4. EOS006215

EOS006215 is a humanized monoclonal antibody inhibitor targeting TREM-2. EOS006215 reprograms TREM2+ macrophages, significantly blocks their pleiotropic pro-tumoral functions and overcomes resistance. EOS215 decreases metastasis burden in orthotopic 4T1 triple negative breast cancer mice model and significantly inhibits tumor growth in anti-PD-1 resistant mice model. EOS006215 can be used to study advanced malignant solid neoplasm, such as triple negative breast cancer (TNBC).

For research use only. We do not sell to patients.

EOS006215 Chemical Structure

EOS006215 Chemical Structure

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EOS006215 Related Antibodies

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TREM-1 TREM-2

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Description

EOS006215 is a humanized monoclonal antibody inhibitor targeting TREM-2. EOS006215 reprograms TREM2+ macrophages, significantly blocks their pleiotropic pro-tumoral functions and overcomes resistance. EOS215 decreases metastasis burden in orthotopic 4T1 triple negative breast cancer mice model and significantly inhibits tumor growth in anti-PD-1 resistant mice model. EOS006215 can be used to study advanced malignant solid neoplasm, such as triple negative breast cancer (TNBC)[1].

IC50 & Target[1]

TREM-2

 

Gene ID

54209  [NCBI]

Accession

Q9NZC2-1
Target

TREM-2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EOS006215 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EOS006215EOS-215EOS 006215EOS-006215EOS215EOS 215TREM receptorTriggering receptors expressed on myeloid cellsTREM-2Monoclonal antibodyMacrophagesPro-tumoralOrthotopic 4T1 triple negative breast cancer mice modelTriple negative breast cancerTNBCInhibitorinhibitorinhibit

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EOS006215
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