2. Signaling Pathways
  3. Immunology/Inflammation
  4. TREM receptor
  5. TREM-2 Isoform

TREM-2

 

TREM-2 Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-P991220
    AL002
    		Agonist 98.01%
    AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and a TREM2 agonist antibody for use in neurological disease research.
  • HY-174378
    TREM2 agonist-4
    		Inhibitor
    TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease.
  • HY-W010270A
    Aurothiomalate disodium
    		Activator
    Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis.
  • HY-174369
    TREM2 agonist-3
    		Antagonist
    TREM2 agonist-3 (Compound 4i) is a TREM2 agonist, with a KD value of 19.0 µM. TREM2 agonist-3 shows a KD value of 39.8 µM for TREM1. TREM2 agonist-3 induces an increase in phospho-SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases involving TREM2 dysfunction.
  • HY-P991621
    EOS006215
    		Inhibitor
    EOS006215 is a humanized monoclonal antibody inhibitor targeting TREM-2. EOS006215 reprograms TREM2+ macrophages, significantly blocks their pleiotropic pro-tumoral functions and overcomes resistance. EOS215 decreases metastasis burden in orthotopic 4T1 triple negative breast cancer mice model and significantly inhibits tumor growth in anti-PD-1 resistant mice model. EOS006215 can be used to study advanced malignant solid neoplasm, such as triple negative breast cancer (TNBC).
  • HY-P991442
    DNL-919
    		Agonist
    DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).