2. Signaling Pathways
  3. Immunology/Inflammation
  4. TREM receptor
  5. TREM-2 Isoform

TREM-2

 

TREM-2 Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-P991441
    VGL101
    		Agonist
    VGL101 is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. VGL101 is a pSYK agonist (EC50: 0.77 nM). VGL101 restores the survival ability of microglia and monocyte-derived macrophages under ALSP pathological conditions, inhibits apoptosis, and promotes the restoration of cell morphology to a state similar to that of normal activated CSF1R. VGL101 can be used in Leukoencephalopathies research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P991442
    DNL-919
    		Agonist
    DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-W010270A
    Aurothiomalate disodium
    		Activator
    Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis.
  • HY-P991220
    AL002
    		Agonist
    AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and a TREM2 agonist antibody for use in neurological disease research.