2. Signaling Pathways
  3. Immunology/Inflammation
  4. TREM receptor
  5. TREM-2 Isoform
  6. TREM-2 Inhibitor

TREM-2 Inhibitor

TREM-2 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-174378
    TREM2 agonist-4
    		Inhibitor
    TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease.
  • HY-P991621
    EOS006215
    		Inhibitor
    EOS006215 is a humanized monoclonal antibody inhibitor targeting TREM-2. EOS006215 reprograms TREM2+ macrophages, significantly blocks their pleiotropic pro-tumoral functions and overcomes resistance. EOS215 decreases metastasis burden in orthotopic 4T1 triple negative breast cancer mice model and significantly inhibits tumor growth in anti-PD-1 resistant mice model. EOS006215 can be used to study advanced malignant solid neoplasm, such as triple negative breast cancer (TNBC).