2. Signaling Pathways
  3. Immunology/Inflammation
  4. TREM receptor
  5. TREM-2 Isoform
  6. TREM-2 Agonist

TREM-2 Agonist

TREM-2 Agonists (4):

Cat. No. Product Name Effect Purity
  • HY-P991220
    AL002
    		Agonist 98.01%
    AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and a TREM2 agonist antibody for use in neurological disease research.
  • HY-175510
    TREM2 agonist-5
    		Agonist 99.61%
    TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease.
  • HY-P991442
    DNL-919
    		Agonist
    DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P991734
    VHB937
    		Agonist
    VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research.