2. Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Lipoxygenase Interleukin Related TNF Receptor IFNAR
  4. 5-LOX-IN-8

5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD).

For research use only. We do not sell to patients.

5-LOX-IN-8 Chemical Structure

5-LOX-IN-8 Chemical Structure

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5-LOX-IN-8 Related Antibodies

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Description

5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD)[1].

IC50 & Target[1]

5-LOX

 

IL-6

 

IL-1β

 

IL-8

 

In Vitro

5-LOX-IN-8 (Compound 18d) (0.3-50 μM, 24 h) shows cytotoxicity in THP-1 cell (IC50: 37.65 μM) and SW 480 cell (IC50: 14.37 μM)[1].
5-LOX-IN-8 (10 μM, 5 min) inhibits human recombinant 5-LOX by 40.65%, and also inhibits NO production by 38.85% in SW480 cells[1].
5-LOX-IN-8 (10 μM, 1 h pretreatment and 24 h co-culture with LPS) suppresses IL-6 (93.98%), IL-1β (19.41%), TNF-α (45.97%) and IFN-γ (66.61%) production in LPS (HY-D1056)-stimulated THP-1 macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-LOX-IN-8 Related Antibodies

Cell Viability Assay[1]

Cell Line: THP-1 cell, SW 480 cell
Concentration: 0.3-50 μM
Incubation Time: 24 h
Result: Inhibited the cell viability of THP-1 cell (IC50: 37.65 μM) and SW 480 cell (IC50: 14.37 μM).
And the cell viability of THP-1 cell and SW 480 cell at 50 μM were 65.54% and 56.23%, respectively.
In Vivo

5-LOX-IN-8 (Compound 18d) (30 mg/kg) reduces disease activity in 5% DSS (HY-116282C) induced murine colitis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5% DSS (v/v, in drinking water, every second day) murine colitis model
Dosage: 30 mg/kg
Administration:
Result: Increased the body weight (87.84%) compared with DSS-treated group (73.75%).
Slightly increased the colon length (mm) compared with DSS-treated group.
Significantly reduced DAI from Day-4 to Day-7, with a Day-7 DAI of 8.67 compared to 11.67 for the DSS-treated group.
Molecular Weight

478.58

Formula

C29H34O6
SMILES

COC1=C(OC)C(OC)=CC(CC2(CC3=CC(OC)=C(OC)C(OC)=C3)CC4=C(C=CC=C4)C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5-LOX-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-LOX-IN-8LipoxygenaseInterleukin RelatedTNF ReceptorIFNARLOXILTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptoranti-inflammatoryIL-6IL-1βTNF-αIFN-γmacrophagesDSScolitisinflammatory bowel diseaseIBDInhibitorinhibitorinhibit

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HY-173180
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