Poly (I:C):Kanamycin (1:1)

Name: Poly (I:C):Kanamycin (1:1)
Brand: MedChemExpress
SKU: HY-107202A
Rating: 5.0 (33 reviews)

Cat. No.: HY-107202A Assay: 51.00%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Poly (I:C):Kanamycin (1:1) is a mixture of poly (I:C) and kanamycin. Poly(I:C) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Kanamycin is positively charged (poly-NH3) and can thus neutralize the negative charge of Poly I:C and thereby stabilized the molecule.

For research use only. We do not sell to patients.

Poly (I:C):Kanamycin (1:1) Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 33 publication(s) in Google Scholar

Other Forms of Poly (I:C):Kanamycin (1:1):

Polyinosinic-polycytidylic acid Get quote
Polyinosinic-polycytidylic acid potassium Get quote
Polyinosinic-polycytidylic acid sodium Get quote
Poly (I:C):Kanamycin (1:1) (sodium) Get quote

28 Publications Citing Use of MCE Poly (I:C):Kanamycin (1:1)

RT-PCR

: Poly (I:C):Kanamycin (1:1) purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 May 18. [Abstract]; BECN1 knockout HeLa cells were transfected with pCAGGS, HA-8A or HA-NSs for 24 h, and then transfected with poly(I:C) for 24 h. IFNB, IFIT1 and CXCL10 mRNA levels were analyzed with RT-qPCR.

: Poly (I:C):Kanamycin (1:1) purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 May 18. [Abstract]; HEK293T cells were transfected with pCAGGS, HA-NSs and HA-8A, HA-PxxP, HA-DWP, or HA-WxxL at a dose of 2 μg for 24 h, and then transfected with poly(I:C) for 24 h. IFNB and IFIT1 mRNA levels were analyzed with RT-qPCR.

: Poly (I:C):Kanamycin (1:1) purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 May 18. [Abstract]; HEK293T cells were transfected with HA-8A or HA-NSs at a dose of 2 μg for 24 h, and then transfected with poly(I:C) for 24 h. Co-IP with HA antibodies and evaluation of LC3, TBK1 and TRIM25 with western blot using IgG as control.

: Poly (I:C):Kanamycin (1:1) purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 May 18. [Abstract]; HeLa cells were transfected with pCAGGS, HA-8A or HA-NSs at a dose of 2 μg for 24 h, and then transfected with poly(I:C) for 24 h. IFNB, IFIT1 and CXCL10 mRNA levels were analyzed with RT-qPCR.

: Poly (I:C):Kanamycin (1:1) purchased from MedChemExpress. Usage Cited in: Chem Eng J. 2021 Aug 15;418:129392.; Immunofluorescence staining photographs of lung sections. Scale bars, 100 μm. (I: PBS, II: Poly(I:C), III: PL-Poly(I:C), IV: NL-Poly(I:C), V: PL-Poly(I:C)/RBD, VI: NL-Poly(I:C)/RBD).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Appearance

Solid

Color

White to off-white

SMILES

[Poly(I:C):Kanamycin(1:1)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (Need ultrasonic)

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 20 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 51.00%

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Data Sheet (268 KB) SDS (251 KB)

COA (241 KB)

Handling Instructions (2659 KB)

References

[1]. Matsumoto M, et al. TLR3: interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev. 2008 Apr 29;60(7):805-12. [Content Brief]