2. Cell Cycle/DNA Damage Stem Cell/Wnt Anti-infection
  3. Casein Kinase SARS-CoV
  4. CK2-IN-15

CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase CK2 inhibitor with an IC50 value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases.

For research use only. We do not sell to patients.

CK2-IN-15 Chemical Structure

CK2-IN-15 Chemical Structure

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CK2-IN-15 Related Antibodies

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Description

CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase CK2 inhibitor with an IC50 value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases[1].

IC50 & Target

CK2α

51 pM (IC50)

Molecular Weight

567.12

Formula

C34H35ClN4O2
SMILES

O=C(C1=CC=C2C(N=C(NCCCCCCCCNCC3=CC=C(C4=CC=CC=C4)C(Cl)=C3)C5=C2C=NC=C5)=C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CK2-IN-15 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK2-IN-15Casein KinaseSARS-CoVSARS coronavirusCK2SARS-CoV-2β-coronavirus infection-related diseasesInhibitorinhibitorinhibit

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