2. PI3K/Akt/mTOR
  3. PI3K
  4. HM5023507

HM5023507 is an orally active and selective PI3Kδ/γ inhibitor with IC50s of 4  and 5  μM for PI3Kδ and PI3Kγ over PI3Kβ and PI3Kα. HM5023507 attenuates the PI3Kδ/γ signaling in human basophils. HM5023507 also attenuates the activation and function of human B and T cells and cytokine and IgG production during cocultures, and Th17 differentiation of CD4 T cells. HM5023507 inhibited semiestablished collagen-induced arthritic inflammation in the rat models. HM5023507 can be used for inflammatory diseases like rheumatoid arthritis research.

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HM5023507

HM5023507 Chemical Structure

CAS No. : 1549766-06-4

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HM5023507 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

HM5023507 is an orally active and selective PI3Kδ/γ inhibitor with IC50s of 4  and 5  μM for PI3Kδ and PI3Kγ over PI3Kβ and PI3Kα. HM5023507 attenuates the PI3Kδ/γ signaling in human basophils. HM5023507 also attenuates the activation and function of human B and T cells and cytokine and IgG production during cocultures, and Th17 differentiation of CD4 T cells. HM5023507 inhibited semiestablished collagen-induced arthritic inflammation in the rat models. HM5023507 can be used for inflammatory diseases like rheumatoid arthritis research[1].

IC50 & Target[1]

PI3Kδ

5 nM (IC50)

PI3Kγ

4 nM (IC50)

p110α

590 nM (IC50)

p110β

3960 nM (IC50)

Molecular Weight

435.87

Formula

C21H18ClN7O2
CAS No.
SMILES

O=C1N(C2=CC=CC=C2)C([C@H]3N(C4=NC(N)=NC=C4C(C)=O)CC3)=NN5C1=C(C=C5)Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HM5023507 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HM50235071549766-06-4HM 5023507HM-5023507PI3KPhosphoinositide 3-kinaseInhibitorPI3Kδ/γB cellsT cellsTh17Rheumatoid arthritisinhibitorinhibit

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