2. Apoptosis Epigenetics Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Epigenetic Reader Domain Reactive Oxygen Species (ROS) Glutathione Peroxidase
  4. ATF3-IN-1

ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke.

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ATF3-IN-1

ATF3-IN-1 Chemical Structure

CAS No. : 2952703-90-9

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ATF3-IN-1 Related Antibodies

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Description

ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke[1].

In Vitro

ATF3-IN-1 (Compound 1c) (0.1-2 μM) eases I/R injury by inhibiting oxidative stress and ferroptosis in primary cortical neurons oxygen-glucose deprivation (OGD) models[1].

ATF3-IN-1 (0.1-2 μM) has no cytotoxicity in rat cortical neurons without OGD[1].

ATF3-IN-1 attenuates ferroptosis and reduces I/R injury through the ATF3/SLC7A11/GPX4 axis in primary cortical neurons OGD models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATF3-IN-1 Related Antibodies
In Vivo

ATF3-IN-1 (Compound 1c) (2 mg/kg, ICV, single dose) reduces infarct volume and promotes neurological recovery after cerebral I/R injury by regulating the ATF3/SLC7A11/GPX4 axis, oxidative stress, and ferroptosis in the rat middle cerebral artery occlusion (MCAO) model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (250 g, Six-week-old) MCAO model[1]
Dosage: 2 mg/kg
Administration: ICV, once
Result: Inhibited ATF3 expression and reduces ROS production, Upregulated SLC7A11 and GPX4 expression.
Molecular Weight

451.55

Formula

C24H37NO7
CAS No.
SMILES

O=C(N1CCOCC1)OCCCCCCCCCCC2=C(C)C(C(OC)=C(OC)C2=O)=O
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Purity & Documentation
References
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ATF3-IN-1 Related Classifications

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Keywords:

ATF3-IN-12952703-90-9FerroptosisEpigenetic Reader DomainReactive Oxygen Species (ROS)Glutathione PeroxidaseInhibitorIschemic strokeOGD modelsMCAO modelinhibitorinhibit

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