2. Immunology/Inflammation NF-κB
  3. Toll-like Receptor (TLR) NF-κB Interleukin Related
  4. AN-3485 hydrochloride

AN-3485 hydrochloride is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 hydrochloride can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 hydrochloride also has certain anti-tumor activity.

For research use only. We do not sell to patients.

AN-3485 hydrochloride Chemical Structure

AN-3485 hydrochloride Chemical Structure

CAS No. : 1213786-72-1

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AN-3485 hydrochloride Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

AN-3485 hydrochloride is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 hydrochloride can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 hydrochloride also has certain anti-tumor activity[1][2].

IC50 & Target[2]

TLR2

 

TLR3

 

TLR4

 

TLR5

 

IL-6

 

IL-1β

 

In Vitro

AN-3485 (0-72 h) hydrochloride can inhibit the enhanced cell proliferation, migration, and invasion abilities and suppress the NF-κB signaling pathway in H1975 cells treated with PN1-overexpressing exosomes, indicating that it can weaken the promoting effect of PN1 on the malignant phenotypes of lung cancer cells[1].
AN-3485 (0-100 μM; 0-24 h) hydrochloride can inhibit the expression and release of TNF-α, IL-1β, and IL-6 mediated by TLR2, TLR3, TLR4, and TLR5 in PBMCs and isolated monocytes (IC50: 18-580 nM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AN-3485 hydrochloride Related Antibodies
In Vivo

AN-3485 (35 mg/kg; oral administration; twice daily; 20 days) hydrochloride has an ameliorating effect in a Collagen (HY-NP003)-induced murine arthritis model[2].
AN-3485 (0.1-1 mg; topically applied to the ears; twice) hydrochloride can significantly inhibit PMA (HY-18739)-induced contact dermatitis and Oxazolone (HY-126360)-induced delayed-type hypersensitivity in mice, as well as the production of cytokines such as IL-1β and IL-6[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1J male mice aged 6-7 weeks old treated collagen (HY-NP003)[2]
Dosage: 35 mg/kg
Administration: Oral administration (p.o.); twice daily for 20 days
Result: Inhibited the rate of disease progression, and the cumulative disease score increased less compared with the vehicle-treated group.
Alleviated joint inflammation and damage, including synovial inflammation, pannus formation, cartilage damage, and bone resorption.
Molecular Weight

325.98

Formula

C14H14BCl2NO3
CAS No.
SMILES

OB1OCC2=CC=C(C=C12)OC3=CC=C(C=C3Cl)CN.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AN-3485 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN-34851213786-72-1AN3485AN 3485Toll-like Receptor (TLR)NF-κBInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILarthritis modelH1975 cellsPBMCsmonocytesInhibitorinhibitorinhibit

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