2. Metabolic Enzyme/Protease Neuronal Signaling NF-κB
  3. Phosphatase Tau Protein NF-κB
  4. Quercetagitrin

Quercetagitrin  (Synonyms: Quercetagetin-7-O-glucoside)

Cat. No.: HY-N4150 Purity: 98.34%
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Handling Instructions Technical Support

Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes.

For research use only. We do not sell to patients.

Quercetagitrin

Quercetagitrin Chemical Structure

CAS No. : 548-75-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Quercetagitrin:

Quercetagitrin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes[1][2][3][4].

In Vitro

Quercetagitrin (3.12-100 μM, 0-48 h) decreases the peak flurorescence and inhibits tau-K18 aggregation in a dose-dependent manner[3].
Quercetagitrin (10-40 μM, 24 h) decreases tau phosphorylation levels and total tau levels concentration-dependently in HEK293 cells transfected with human 1N4R P301S-tau plasmids sup>[3].
Quercetagitrin (10-20 μM, 24 h) decreases tau phosphorylation levels and total tau levels concentration-dependently in N2a cells transfected with human 1N4R P301S-tau plasmids sup>[3].
Quercetagitrin (Compound QG) inhibits PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM)[4].
Quercetagitrin (2.5-5 μM, 6 h) increases glucose absorption in the prescence of insulin in differentiated C2C12 myoblasts[4].
Quercetagitrin (5-10 μM, 6 h) increases AMPK phosphorylation in C2C12 myoblasts[4].
Quercetagitrin (40 μM, 6 h) mitigates palmitic acid-induced insulin resistance in C2C12 myoblast through the insulin-dependent Akt pathway[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quercetagitrin Related Antibodies
In Vivo

Quercetagitrin (10 μg/mL, through water feeding, 3 consecutive months) attenuates synaptic impairments and cognitive deficits in the P301S-Tau transgenic mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-month-old male P301S-Tau transgenic mice[3]
Dosage: 10 μg/mL
Administration: Through water feeding for 3 consecutive months
Result: Remarkably decreased acetylation level at Lys174.
Reduced tau accumulation in the hippocampus and the cortex.
Prevented augmented GSK3β activity in the hippocampus.
Reduced tau oligomerization.
Prominently limited astrogliosis and microglia activation in the hippocampus of P301S-tau transgenic mice.
Partially elevated synaptophysin expression and efficiently ameliorated the memory deficits in P301S-tau transgenic mice, evidenced by decreased latency in reaching the target platform region.
Reduced gliosis, neuronal loss, synaptic impairments and cognitive deficits.
Molecular Weight

480.38

Formula

C21H20O13
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(O)C(O)=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC(C4=CC(O)=C(O)C=C4)=C1O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (260.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0817 mL 10.4084 mL 20.8169 mL
5 mM 0.4163 mL 2.0817 mL 4.1634 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
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%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.34%

SDS (252 KB)

COA (251 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0817 mL 10.4084 mL 20.8169 mL 52.0421 mL
5 mM 0.4163 mL 2.0817 mL 4.1634 mL 10.4084 mL
10 mM 0.2082 mL 1.0408 mL 2.0817 mL 5.2042 mL
15 mM 0.1388 mL 0.6939 mL 1.3878 mL 3.4695 mL
20 mM 0.1041 mL 0.5204 mL 1.0408 mL 2.6021 mL
25 mM 0.0833 mL 0.4163 mL 0.8327 mL 2.0817 mL
30 mM 0.0694 mL 0.3469 mL 0.6939 mL 1.7347 mL
40 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3011 mL
50 mM 0.0416 mL 0.2082 mL 0.4163 mL 1.0408 mL
60 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8674 mL
80 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6505 mL
100 mM 0.0208 mL 0.1041 mL 0.2082 mL 0.5204 mL
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Quercetagitrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quercetagitrin548-75-4Quercetagetin-7-O-glucosidePhosphataseTau ProteinNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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