2. Autophagy
  3. p62 Atg8/LC3 Autophagy
  4. Microcolin H

Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models.

For research use only. We do not sell to patients.

Microcolin H Chemical Structure

Microcolin H Chemical Structure

CAS No. : 2408008-21-7

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Based on 1 publication(s) in Google Scholar

Microcolin H Related Antibodies

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Description

Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models[1].

IC50 & Target

Phosphatidylinositol transfer protein, PITPα/β[1]
Molecular Weight

733.93

Formula

C38H63N5O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@H](C=CC1=O)C)[C@H]2N(C[C@H](C2)O)C([C@H](C(C)C)N(C)C([C@H]([C@@H](C)OC(C)=O)NC([C@H](CC(C)C)N(C)C([C@H](C)CCCCCC)=O)=O)=O)=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (68.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3625 mL 6.8126 mL 13.6253 mL
5 mM 0.2725 mL 1.3625 mL 2.7251 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3625 mL 6.8126 mL 13.6253 mL 34.0632 mL
5 mM 0.2725 mL 1.3625 mL 2.7251 mL 6.8126 mL
10 mM 0.1363 mL 0.6813 mL 1.3625 mL 3.4063 mL
15 mM 0.0908 mL 0.4542 mL 0.9084 mL 2.2709 mL
20 mM 0.0681 mL 0.3406 mL 0.6813 mL 1.7032 mL
25 mM 0.0545 mL 0.2725 mL 0.5450 mL 1.3625 mL
30 mM 0.0454 mL 0.2271 mL 0.4542 mL 1.1354 mL
40 mM 0.0341 mL 0.1703 mL 0.3406 mL 0.8516 mL
50 mM 0.0273 mL 0.1363 mL 0.2725 mL 0.6813 mL
60 mM 0.0227 mL 0.1135 mL 0.2271 mL 0.5677 mL
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Microcolin H Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microcolin H2408008-21-7p62Atg8/LC3AutophagySequestosome-1SQSTM1Autophagy-related 8| marine liptideautophagysubcutaneous tumor modelanti-proliferationInhibitorinhibitorinhibit

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