2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. KIT-13

KIT-13 is an orally active plasmalogen derivative to inhibit neuroinflammation and mitochondrial DNA leakage associated with Mecp2 deficiency. KIT-13 significantly reduce neurological symptoms and improves the life span of the Rett Syndrome (RTT) model mice. KIT-13 can be used for the study of RTT and other neuroinflammation-related diseases[1].

For research use only. We do not sell to patients.

KIT-13 Chemical Structure

KIT-13 Chemical Structure

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KIT-13 Related Antibodies

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Description

KIT-13 is an orally active plasmalogen derivative to inhibit neuroinflammation and mitochondrial DNA leakage associated with Mecp2 deficiency. KIT-13 significantly reduce neurological symptoms and improves the life span of the Rett Syndrome (RTT) model mice. KIT-13 can be used for the study of RTT and other neuroinflammation-related diseases[1].

In Vitro

KIT-13 (5-10 g/mL, 48 h, BV2 cells) ameliorates mitochondrial functional deficits induced by Mecp2 gene deletion and mitochondrial membrane potential in Mecp2-KD BV2 cells is restored by treatment with PK11195 (HY-19567) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIT-13 Related Antibodies

Real Time qPCR[1]

Cell Line: Mecp2-knockdown BV2 cells
Concentration:
Incubation Time: 48 h
Result: Decreased levels of four different mtDNA-specific genes (Mt-Rnr2, MT-Co1, Mt-Nd2, Mt-Cytb).

Western Blot Analysis[1]

Cell Line: BV2 cells
Concentration: 5 µg/mL
Incubation Time: 48 h
Result: Reduced TSPO expression.
In Vivo

KIT-13 (20 μg/kg, p.o., 6 weeks, daily) improves neurological symptoms and restores healthy microglia morphology in RTT mice brain tissue[1].


KIT-13 (p.o., 2 weeks, daily ) attenuates abnormalities in social and anxiety-like behavior in RTT model mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mecp2-KO in C57BL/6 mice (4 weeks)
Dosage: Mecp2-KO in C57BL/6 mice (4 weeks)
Administration: Daily oral administration 6 weeks
Result: Improved the survival of Mecp2-KO mice and reduced the RTT neurological symptom score including improvement of the general condition of the Mecp2-KO mice more effectively compared with Plasmaloge, KIT-08, KIT19 or KIT20.
Reduced the soma size and increased the dendrite length in the Mecp2-KO mice, partially restoring a healthy phenotype.
Molecular Weight

754.07

Formula

C43H80NO7P
SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@@H](CO[P@]([O-])(OCC[NH3+])=O)COCCCCCCCCCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KIT-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIT-13KIT13KIT 13Mitochondrial MetabolismneuroinflammationMecp2RTTmitochondrial DNA leakageBV2Inhibitorinhibitorinhibit

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