SB-T-1214 

SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133⁺/CD44^{+ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers[1][2].}

SB-T-1214 (0.5-5000 nM, 72 h) has potent FR-specific anticancer activity with IC₅₀s of 2.82, 1.89 , 2.66 and 4.89 nM for ID8, MX-1, L1210-FR and WI-38 cells^[1].
SB-T-1214 (0.1-1 μM, 48 h) induces apoptosis in CSC-enriched colon cancer cells and spheroids with a loss of integrity of the floating spheroids and 1.5-3% secondary spheroids production in HCT116, HT29 and DLD-1 cells at 0.1 μM^[2].
SB-T-1214 (0.1 μM, 24-24 h) significantly down-regulates a majority of the stemness genes such as SOX1, ACAN, and COL1A1 and inhibits the protein expression of pluripotency markers Oct4, Sox2, and c-Myc in spheroids from CD133+/CD44+ HCT116, HT29 and DLD-1 cells ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB-T-1214 (10-40  mg/kg, i.p., i.v., q3d × 3 (day 5, 8, and 11)) strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model with great efficacy at 20 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

853.95

C₄₅H₅₉NO₁₅

178250-23-2

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Seitz JD, et al. Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate. Bioorg Med Chem. 2015 May 1; 23(9):2187-94.  [Content Brief]

  [2]. Botchkina GI, et al. New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells. Mol Cancer. 2010 Jul 14; 9:192.  [Content Brief]