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  4. Antimalarial agent 50

Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria[1].

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Antimalarial agent 50 Chemical Structure

Antimalarial agent 50 Chemical Structure

CAS No. : 2384242-67-3

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Antimalarial agent 50 Related Antibodies

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Description

Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria[1].

In Vivo

Antimalarial agent 50 (Compound 3a) (200-800 μg/kg; i.p.; once daily; for 4 days) can dose dependently reduce parasitic infections in a mouse model of malaria parasite infection and exhibits anti-inflammatory and antioxidant potential[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. berghei NK 65 strain injected male Balb/c mice model (6-8 weeks)[1].
Dosage: 200-800 μg/kg, Positive control group Chloroquine (HY-17589A)
Administration: Intraperitoneal injection (i.p.)
Result: Showed the best anti parasitemia effect at 800 µg/kg with the inhibition rate of 83.6 %.
Restored RBCs similar to the vehicle control group.
Improved the condition of the ruffled fur and anxiety.
Significantly reversed RBCs, Hb, PCV, MCV, MCH, MCHC and platelets of infected mice.
Significantly reduced the concentration of AST, ALP, ALT and bilirubin, creatinine, uric acid and improved the pathological structure of the liver and spleen.
Improved the concentration of GSH, GST and CAT and reduced the concentration of NO and MDA.
Restored blood sugar levels in the infected mice.
Reduced the level of inflammatory factors NF-κB, IL-6, IFN-γ and decreased the level of the TNF-α, iNOS, IL-1β
Molecular Weight

410.49

Formula

C24H18N4OS
CAS No.
SMILES

O=C(N1N=C(C2=CC=CC=C2)C=C1C3=CC=CC=C3)CSC4=NC5=CC=CC=C5N4
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Antimalarial agent 50 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 502384242-67-3Antimalarial agent50Antimalarial agent-50ParasiteAntimalarials Plasmodium bergheiParasitemiaInflammationOxidative stressInhibitorinhibitorinhibit

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