Ditiocarb sodium,98% (Synonyms: Sodium diethyldithiocarbamate,98%)

Name: Ditiocarb sodium,98%
Brand: MedChemExpress
SKU: HY-B1637A
Rating: 5.0 (3 reviews)

Cat. No.: HY-B1637A Purity: 99.2%: Data Sheet
SDS

COA
Handling Instructions
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Ditiocarb sodium,98% (Sodium diethyldithiocarbamate,98%) is an orally active copper reagent. Ditiocarb sodium,98% exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium,98% can be used in the research of tumors, inflammatory, and immune-related diseases.

For research use only. We do not sell to patients.

Ditiocarb sodium,98% Chemical Structure

CAS No. : 148-18-5

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
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Based on 3 publication(s) in Google Scholar

Other Forms of Ditiocarb sodium,98%:

Ditiocarb sodium In-stock

3 Publications Citing Use of MCE Ditiocarb sodium,98%

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References
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Description

In Vitro

Ditiocarb sodium,98% can act as an accelerator in the cementation of copper from copper sulfate solution on zinc. It reacts with Cu²⁺ solution to form a copper diethyldithiocarbamate complex, thereby increasing the rate of copper cementation. The higher its concentration, the more significant the increase in the cementation rate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ditiocarb (500-750 mg/kg; intraperitoneal injection; single dose) sodium,98% can inhibit Cisplatin (HY-17394)-induced nephrotoxicity and gastrointestinal toxicity in rats^[3].
Ditiocarb (80-100 μmol; intraperitoneal injection; twice a week; 22 weeks) sodium,98% exhibits antitumor activity in a mouse skin tumor model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male F344 rats treated Cisplatin (HY-17394)^[3]
Dosage:	500 and 750 mg/kg
Administration:	Intraperitoneal injection; single dose: between 1 and 4 hr after Cisplatin administration
Result:	Significantly reduced serum BUN levels. Alleviated weight loss, eliminated diarrhea. Improved renal histology with only minimal degeneration at the corticomedullary junction, while administration at 6 hours after cis-platinum was ineffective.

Animal Model:	Female CF-1 mice aged 7-9 weeks old treated DMBA (HY-W011845) and TPA (HY-18739) or Mezerein^[4]
Dosage:	80 and 100 μmol
Administration:	Intraperitoneal injection; twice a week; 22 weeks
Result:	Significantly inhibited complete tumor promotion by TPA and stage 2 promotion by mezerein. Reduced TPA-decreased GSH peroxidase and TPA-induced ODC activities. Suppressed TPA-stimulated DNA synthesis.

Molecular Weight

171.26

Formula

C₅H₁₀NNaS₂

CAS No.

148-18-5

Appearance

Solid

Color

White to light brown

SMILES

S=C(S[Na])N(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (583.91 mM; Need ultrasonic)

DMSO : 50 mg/mL (291.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8391 mL	29.1954 mL	58.3908 mL
5 mM	1.1678 mL	5.8391 mL	11.6782 mL
10 mM	0.5839 mL	2.9195 mL	5.8391 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (29.20 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (29.20 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (29.20 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.2%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (247 KB) HNMR (109 KB)

Handling Instructions (2659 KB)

References

[1]. Abeer A.El-Saharty, et al. Sodium diethyldithiocarbamate as accelerator of the rate of copper cementation. The Egyptian Journal of Aquatic Research. 2015 Dec, Volume 41(4):289-293.

[2]. Hersh EM, et al. Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS. A randomized, double-blind, placebo-controlled, multicenter study. JAMA. 1991 Mar 27;265(12):1538-44. [Content Brief]

[3]. Borch RF, et al. Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6611-4. [Content Brief]

[4]. Perchellet JP, et al. Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate. Cancer Res. 1987 Dec 1;47(23):6302-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.8391 mL	29.1954 mL	58.3908 mL	145.9769 mL
	5 mM	1.1678 mL	5.8391 mL	11.6782 mL	29.1954 mL
	10 mM	0.5839 mL	2.9195 mL	5.8391 mL	14.5977 mL
	15 mM	0.3893 mL	1.9464 mL	3.8927 mL	9.7318 mL
	20 mM	0.2920 mL	1.4598 mL	2.9195 mL	7.2988 mL
	25 mM	0.2336 mL	1.1678 mL	2.3356 mL	5.8391 mL
	30 mM	0.1946 mL	0.9732 mL	1.9464 mL	4.8659 mL
	40 mM	0.1460 mL	0.7299 mL	1.4598 mL	3.6494 mL
	50 mM	0.1168 mL	0.5839 mL	1.1678 mL	2.9195 mL
	60 mM	0.0973 mL	0.4866 mL	0.9732 mL	2.4329 mL
	80 mM	0.0730 mL	0.3649 mL	0.7299 mL	1.8247 mL
	100 mM	0.0584 mL	0.2920 mL	0.5839 mL	1.4598 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Ditiocarb sodium,98% Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ditiocarb sodium,98%148-18-5Sodium diethyldithiocarbamate,98%HIVBiochemical Assay ReagentsHuman immunodeficiency virusCuskin tumor modelInhibitorinhibitorinhibit

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Ditiocarb sodium,98% (Synonyms: Sodium diethyldithiocarbamate,98%)

Customer Review

Other Forms of Ditiocarb sodium,98%:

Ditiocarb sodium,98% Related Antibodies

3 Publications Citing Use of MCE Ditiocarb sodium,98%

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Ditiocarb sodium,98% Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ditiocarb sodium,98% Related Classifications

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