2,4-Dinitrobenzenesulfonic acid sodium salt  (Synonyms: Sodium 2,4-dinitrobenzenesulfonate; DNBS sodium salt; DNBSO sodium salt)

2,4-Dinitrobenzenesulfonic acid (sodium salt) is a hapten. 2,4-Dinitrobenzenesulfonic acid (sodium salt) can induce the proliferation of primary lymphocytes and epithelial cells isolated from guinea pigs that are sensitized to 2, 4-DNCB. 2,4-Dinitrobenzenesulfonic acid (sodium salt) inhibits contact sensitivity induced by 2, 4-DNCB in guinea pigs. 2,4-Dinitrobenzenesulfonic acid (sodium salt) can induce ulcerative colitis in rodent models^[1][2][3].

270.15

C₆H₃N₂NaO₇S

885-62-1

Solid

O=[N+]([O-])C1=CC([N+]([O-])=O)=C(S(=O)(O[Na])=O)C=C1

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Li, Q., & Aoyama, K. (1991). In vitro evaluation on contact sensitivity from DNCB and DNBS using lymphocyte blastogenesis response test. Sangyo igaku. Japanese journal of industrial health, 33(6), 509–518.  [Content Brief]

  [2]. Frey, J. R., et al., (1971). Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene. Clinical and experimental immunology, 8(1), 131–139.  [Content Brief]

  [3]. Kim, S., et al., (2020). A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats. Pharmaceutics, 12(9), 843.  [Content Brief]