LPAR1 antagonist 1

Cat. No.: HY-162267 Purity: 98.85%: Data Sheet
COA

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Handling Instructions
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LPAR1 antagonist 1 (compound 18) is a potent, oral active and selective LPAR1 antagonist with the IC₅₀ of 3.3 nM. LPAR1 antagonist 1 can be used for study of fibrosis.

For research use only. We do not sell to patients.

LPAR1 antagonist 1 Chemical Structure

CAS No. : 3032275-33-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

LPAR1 antagonist 1 (compound 18) is a potent, oral active and selective LPAR1 antagonist with the IC₅₀ of 3.3 nM. LPAR1 antagonist 1 can be used for study of fibrosis^[1].

Molecular Weight

466.57

Formula

C₂₇H₃₄N₂O₅

CAS No.

3032275-33-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC(N1CCC(C2=C(C(C)C)C=CC=C2)(CC1)C(NC3=CC=C(C)C=C3OC)=O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (133.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1433 mL	10.7165 mL	21.4330 mL
5 mM	0.4287 mL	2.1433 mL	4.2866 mL
10 mM	0.2143 mL	1.0717 mL	2.1433 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.85%

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Data Sheet (273 KB) SDS (251 KB)

COA (256 KB) HNMR (307 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Lescop C, et al. Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, with a Distinct Molecular Scaffold. J Med Chem. 2024 Feb 22;67(4):2379-2396. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1433 mL	10.7165 mL	21.4330 mL	53.5825 mL
	5 mM	0.4287 mL	2.1433 mL	4.2866 mL	10.7165 mL
	10 mM	0.2143 mL	1.0717 mL	2.1433 mL	5.3583 mL
	15 mM	0.1429 mL	0.7144 mL	1.4289 mL	3.5722 mL
	20 mM	0.1072 mL	0.5358 mL	1.0717 mL	2.6791 mL
	25 mM	0.0857 mL	0.4287 mL	0.8573 mL	2.1433 mL
	30 mM	0.0714 mL	0.3572 mL	0.7144 mL	1.7861 mL
	40 mM	0.0536 mL	0.2679 mL	0.5358 mL	1.3396 mL
	50 mM	0.0429 mL	0.2143 mL	0.4287 mL	1.0717 mL
	60 mM	0.0357 mL	0.1786 mL	0.3572 mL	0.8930 mL
	80 mM	0.0268 mL	0.1340 mL	0.2679 mL	0.6698 mL
	100 mM	0.0214 mL	0.1072 mL	0.2143 mL	0.5358 mL