2. Signaling Pathways
  3. Neuronal Signaling
  4. TSPO

TSPO

Translocator Protein

TSPO (Translocator Protein) is a conserved membrane protein located on the outer mitochondrial membrane of eukaryotic cells, with the 18 kDa subtype being the most studied in mammals. It regulates steroid synthesis, mitochondrial function, apoptosis, and immune responses, influencing mitochondrial membrane permeability, energy metabolism, and cellular stress through pathways such as PKA, MAPK, and NF-κB. TSPO plays a significant role in neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), psychiatric disorders (e.g., anxiety, depression), cancer, and inflammatory diseases, with its altered expression making it a potential target for diagnosis and therapy[1].

TSPO Related Products (4):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-122607
    DPA-714
    		99.86%
    DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
    DPA-714
  • HY-150409
    TSPO ligand-2
    		Ligand 99.63%
    TSPO ligand-2 is a ligand of AUTAC1. AUTAC1 contains an p-fluorobenzylguanine (FBnG) and a Fumagillol moiety, which can silence endogenous MetAP2 in HeLa cells.
    TSPO ligand-2
  • HY-175340
    Kv7.2/Kv7.3 activator-3
    		Activator
    Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2/Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and binds to TSPO with Ki values of 0.07 μM (rat membrane) and 4.60 μM (human U-118 MG cells). Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and Kv7.2/3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons.
    Kv7.2/Kv7.3 activator-3
  • HY-172534
    BPN-01
    BPN-01 is a fluorescent probe targeting translocator protein (TSPO) and human epidermal growth factor receptor 2 (HER2) with binding affinities of -10.7 kcal/mol for TSPO and -11.3 kcal/mol for HER2. BPN-01 is promising for research of solid tumor imaging during fluorescence image-guided surgery (FIGS) (Ex/Em = 475/510 nm).
    BPN-01