BPN-01 

BPN-01 is a fluorescent probe targeting translocator protein (TSPO) and human epidermal growth factor receptor 2 (HER2) with binding affinities of -10.7 kcal/mol for TSPO and -11.3 kcal/mol for HER2. BPN-01 is promising for research of solid tumor imaging during fluorescence image-guided surgery (FIGS) (Ex/Em = 475/510 nm)^[1].

BPN-01 (3.91 μg/mL, 7.81 μg/mL, 15.63 μg/mL, 31.25 μg/mL, 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL; 48 h; B16-F10) maintains B16-F10 cell viability at ~100% across all concentrations^[1].
BPN-01 (0.01 mM, 0.05 mM, 0.1 mM, 0.5 mM, 1.0 mM; 24 h; DU-145, B16-F10, C2C12) stains DU-145 and B16-F10 cancer cells at 0.01 mM but not at higher concentrations or in C2C12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPN-01 (0.1 mM; IV; 3 h) enhances tumor visualization in prostate cancer-bearing mice, with preferential accumulation in tumor tissues and minimal retention in normal organs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

476.46

C₂₂H₁₆N₆O₅S

COC1=CC=C2C(SC(C(NC3=CC=C(C=C3)CNC4=CC=C(C5=NON=C45)[N+]([O-])=O)=O)=N2)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wongso H, et al. Synthesis and Biological Evaluation of New Fluorescent Probe BPN-01: A Model Molecule for Fluorescence Image-guided Surgery. J Fluoresc. 2023 Sep;33(5):1827-1839.  [Content Brief]