2. Membrane Transporter/Ion Channel Apoptosis
  3. Sec61 Apoptosis Caspase
  4. KZR-261

KZR-261 is a Sec61 inhibitor. KZR-261 directly binds to the Sec61 channel to potently inhibit the biogenesis of a subset of Sec61 client proteins. KZR-261 has a broad antitumor activity (such as colorectal pancreas and prostate cancer), along with the activation of an endoplasmic reticulum stress response, with minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis of H929 cells. KZR-261 potently inhibits tumor growth in multiple xenograft tumor mice models with good tolerance.

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KZR-261

KZR-261 Chemical Structure

CAS No. : 2376747-46-3

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KZR-261 Related Antibodies

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Description

KZR-261 is a Sec61 inhibitor. KZR-261 directly binds to the Sec61 channel to potently inhibit the biogenesis of a subset of Sec61 client proteins. KZR-261 has a broad antitumor activity (such as colorectal pancreas and prostate cancer), along with the activation of an endoplasmic reticulum stress response, with minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis of H929 cells. KZR-261 potently inhibits tumor growth in multiple xenograft tumor mice models with good tolerance[1].

IC50 & Target[1]

Caspase 3

 

Caspase-7

 

Molecular Weight

765.06

Formula

C38H61FN6O5S2
CAS No.
SMILES

O=S(N1CCCN(CCCN(C[C@H](C1)C)S(N2C[C@H](N([C@@H](C2)C)C3=CC(OC)=CC(F)=C3)C)(=O)=O)CC4CCCCC4)(C5=CC=C(C=C5)N(C)C)=O
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Purity & Documentation
References
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KZR-261 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KZR-2612376747-46-3KZR261KZR 261Sec61ApoptosisCaspaseSec61 complex, SecY, Sec61 channel InhibitorAantitumorClient proteinsEndoplasmic reticulum stressXenograft tumor mice modelsNHDFsPBMCsU266 cellsHT29 cellsH82 cellsBxPC-3 cells22Rv1 cellsRL cellsMino cellsColorectal cancerPancreas cancerProstate cancerinhibitorinhibit

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