2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. AMPA-IN-2

AMPA-IN-2 is an orally active AMPA inhibitor that can cross the blood-brain barrier. AMPA-IN-2 improves epileptic seizures by inhibiting the intrinsic excitability of neurons and inhibiting the excitability of glutamatergic transmission. AMPA-IN-2 exerts anti-epileptic effects in the pentylenetetrazol (PTZ) model and can be used as a promising candidates with high broad-spectrum anti-epileptic potential.

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AMPA-IN-2 Chemical Structure

AMPA-IN-2 Chemical Structure

CAS No. : 75828-06-7

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AMPA-IN-2 Related Antibodies

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Description

AMPA-IN-2 is an orally active AMPA inhibitor that can cross the blood-brain barrier. AMPA-IN-2 improves epileptic seizures by inhibiting the intrinsic excitability of neurons and inhibiting the excitability of glutamatergic transmission. AMPA-IN-2 exerts anti-epileptic effects in the pentylenetetrazol (PTZ) model and can be used as a promising candidates with high broad-spectrum anti-epileptic potential[1].

In Vitro

AMPA-IN-2 (compound 13) (1 μM, 10 μM) suppresses the intrinsic excitability of neurons and inhibits the excitability of glutamatergic synaptic transmission[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMPA-IN-2 Related Antibodies
In Vivo

AMPA-IN-2 (compound 13) (100 mg/kg, i.p., once) shows anti-epileptic effect and reduces mortality in the maximal electroshock (MES)-induced epilepsy model[1].

AMPA-IN-2 (30 mg/kg 100 mg/kg, i.p., once) demonstrates high anti-epileptic efficacy in the PTZ-induced epilepsy model[1].

AMPA-IN-2 (100 mg/kg, i.p., once) alleviates the severity seizure in a Chronic Hippocampal-Kindled Epilepsy Model[1].

AMPA-IN-2 (30 mg/kg, p.o., once) shows anti-epileptic effect in the PTZ-induced epilepsy model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The MES-induced epilepsy model[1]
Dosage: 100 mg/kg
Administration: i.p., once
Result: Showed anti-epileptic effect and reduced mortality in the MES-induced epilepsy model
Animal Model: The PTZ-induced epilepsy model[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg, 100 mg/kg
Administration: i.p., once
Result: Prolonged the latency to seizure stages 2, 4, and 6, maintained a lasting therapeutic action, respectively, with no mortality observed.
Animal Model: Chronic Hippocampal-Kindled Epilepsy Model[1]
Dosage: 100 mg/kg
Administration: i.p., once
Result: Attenuated seizure severity in the kindled mice, as demonstrated by a decrease in the behavioral seizure stage from 5.0 to 3.5.
Shortened the generalized seizure duration (GSD) from 17.80 to 9.60 s, but it led to an undesirable increase in the after-discharge duration (ADD).
Molecular Weight

178.27

Formula

C12H18O
CAS No.
SMILES

C[C@]12[C@](O)(C[C@@H](CC2)C1(C)C)C#C
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AMPA-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

AMPA-IN-275828-06-7iGluRIonotropic glutamate receptorsInhibitorEpilepsyThe MES-induced epilepsy modelThe PTZ-induced epilepsy modelChronic Hippocampal-Kindled Epilepsy Modelinhibitorinhibit

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