2. Apoptosis
  3. Apoptosis
  4. BIW-8962

BIW-8962 is a humanized anti-ganglioside GM2 antibody. BIW-8962 exhibits ADCC/CDC activity against multiple myeloma cells. BIW-8962 demonstrates potent anti-tumor activity in mouse xenograft models. BIW-8962 is indicated for research in myeloma and other cancers.

For research use only. We do not sell to patients.

BIW-8962

BIW-8962 Chemical Structure

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Description

BIW-8962 is a humanized anti-ganglioside GM2 antibody. BIW-8962 exhibits ADCC/CDC activity against multiple myeloma cells. BIW-8962 demonstrates potent anti-tumor activity in mouse xenograft models. BIW-8962 is indicated for research in myeloma and other cancers[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

Ganglioside GM2
In Vitro

BIW-8962 (0.01-1 μg/mL) has ADCC activity in GM2-expressing SBC-3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIW-8962 Related Antibodies

Cell Viability Assay[2]

Cell Line: SBC-3 cells
Concentration: 0, 0.1, 1, 10 ug/mL
Incubation Time: 72 h at 37'C
Result: Inhibited cell viability
In Vivo

BIW-8962 (0.1-10 mg/kg, i.v., biweekly for 3-4 weeks) exhibits anti-tumor activity in KMS-11 and OPM-2/GFP severe combined immunodeficiency (SCID) mice model[1].
BIW-8962 (0.1-10 μg/100μL, i.v., once a day, on days 7, 14, 21, 28, and 35 after injection of SBC-3 cells) inhibits tumor multiple organ metastases, increases the number apoptotic cells, prolongs survival in SBC-3 SCID mice depleted of natural killer cells model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KMS-11 SCID mice model[1]
Dosage: 0.1 mg/kg
Administration: i.v., biweekly for 3 weeks
Result: Exhibited a potent anti-tumor activity.
Animal Model: OPM-2/GFP SCID mice model[1]
Dosage: 10 mg/kg
Administration: i.v., biweekly for 4 weeks
Result: Suppressed OPM-2/GFP cell growth and serum M protein elevation.
Animal Model: SBC-3 (106) SCID mice (5-6 weeks) depleted of natural killer cells model[2]
Dosage: 0.1,1,10 μg/100μL
Administration: i.v., once a day, on days 7, 14, 21, 28, and 35 after injection of SBC-3 cells
Result: Inhibited multiple organ metastases of SBC-3 cells, increased the number of TUNEL-positive apoptotic cells, prolonged survival of the mice compared with control.
Target

Ganglioside GM2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BIW-8962 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIW-8962BIW8962BIW 8962Apoptosisanti-ganglioside GM2 antibodymyelomaSBC-3 cellsSCID miceOPM-2/GFP cellsKMS-11 cellsInhibitorinhibitorinhibit

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