2. MAPK/ERK Pathway PI3K/Akt/mTOR NF-κB
  3. p38 MAPK PI3K Akt NF-κB
  4. A2073

A2073 is a flavagline derivative that potently inhibits the proliferation of erythroleukemia cells by causing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways.A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1). A2073 exhibits significant anti-proliferative activity against tumor cells while maintaining a favorable toxicity profile in a zebrafish xenograft tumor model. A2073 can be used for the study of acute erythroleukemia[1].

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A2073 Chemical Structure

A2073 Chemical Structure

CAS No. : 2834742-70-8

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A2073 Related Antibodies

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Description

A2073 is a flavagline derivative that potently inhibits the proliferation of erythroleukemia cells by causing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways.A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1). A2073 exhibits significant anti-proliferative activity against tumor cells while maintaining a favorable toxicity profile in a zebrafish xenograft tumor model. A2073 can be used for the study of acute erythroleukemia[1].

In Vitro

A2073 (25-100 nM, 24-72 h) significantly inhibites the proliferation of HEL and K562 cells in a dose- and time-dependent manner, with IC50 values of 55.02 nM (HEL) and 77.07 nM (K562)[1].

A2073 (25-100 nM, 24-72 h) reduces HEL cell numbers without significantly increasing apoptosis, induces erythroid differentiation in HEL cells as evidenced by increased CD71 expression, and causes cell cycle arrest while downregulating key cell cycle regulatory proteins[1].

A2073 (25-100 nM, 48 h) downregulates key proteins in the MAPK (RAS, RAF, MAPK, MEK), PI3K-AKT (PI3K, AKT), and NF-κB (p-NF-κB, p-IκBα) pathways[1].

A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A2073 Related Antibodies

Cell Viability Assay[1]

Cell Line: HEL cells
Concentration:
Incubation Time: 72 h
Result: Reduced HEL cell numbers more effectively than Cytarabine (Ara-C) (HY-13605), with a lower IC50 (55.02 nM vs. 73.36 nM)

RT-PCR[1]

Cell Line: HEL cells
Concentration: 100 nM
Incubation Time: 48 h
Result: Increased the expression levels of erythroid differentiation markers GATA1, EKLF, SHIP1, and NFE2.

Cell Cycle Analysis[1]

Cell Line: HEL cells
Concentration: 25, 50, 100 nM
Incubation Time: 24, 48, 72 h
Result: Caused cell cycle arrest in the G0 and G2 phases, reduces the proportion of cells in the S phase.

Western Blot Analysis[1]

Cell Line: HEL cells
Concentration: 25, 50, 100 nM
Incubation Time: 48 h
Result: Downregulatesd key cell cycle regulatory proteins including CMYC, CDK1, CDK2, CCNB1, and CCNA2.
In Vivo

A2073 (25-100 nM, 1-5 days) effectively inhibits the proliferation of HEL cells in the zebrafish xenograft tumor model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CM-Dil dye-labeled HEL cells into zebrafish embryos at 48 h post-fertilizations[1]
Dosage: 25, 50, 100 nM
Administration: 1, 3, 5 days
Result: Showed no significant morphological abnormalities (morphology, survival, body length, and heart rate) at any examined time points (1, 3, 5 days) compared to the control group.
Did not induce significant in vivo toxicity in zebrafish embryos.Reduced HEL cell proliferation and migration.
Inhibited the proliferation of HEL cells in the zebrafish xenograft tumor model.
Molecular Weight

559.65

Formula

C33H37NO7
CAS No.
SMILES

O=C(CN1CCCCC1)O[C@@H]2C[C@@H](C3=CC=CC=C3)[C@@]4(C5=CC=C(OC)C=C5)[C@]2(O)C6=C(OC)C=C(OC)C=C6O4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A2073 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A20732834742-70-8A 2073A-2073p38 MAPKPI3KAktNF-κBPhosphoinositide 3-kinasePKBProtein kinase BNuclear factor-κBNuclear factor-kappaBNatural compoundsErythroleukemiaCell cyclePI3K pathwayMAPK pathwayNF-κB pathwayInhibitorinhibitorinhibit

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