2. Immunology/Inflammation
  3. CTLA-4
  4. Anti-Mouse CTLA-4 Antibody (9H10)

Anti-Mouse CTLA-4 Antibody (9H10) 

Cat. No.: HY-P990789 Purity: 95.00%
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Anti-Mouse CTLA-4 Antibody (9H10) is a kind of syrian hamster IgG antibody inhibitor, targeting to CTLA-4. Anti-Mouse CTLA-4 Antibody (9H10) binds mouse CTLA-4 and blocks the interaction between CTLA-4 and its ligand. Anti-Mouse CTLA-4 Antibody (9H10) shows potent anti-tumor effect in various tumor models, such as breast and colon cancer.

For research use only. We do not sell to patients.

Anti-Mouse CTLA-4 Antibody (9H10) Chemical Structure

Anti-Mouse CTLA-4 Antibody (9H10) Chemical Structure

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Description

Anti-Mouse CTLA-4 Antibody (9H10) is a kind of syrian hamster IgG antibody inhibitor, targeting to CTLA-4. Anti-Mouse CTLA-4 Antibody (9H10) binds mouse CTLA-4 and blocks the interaction between CTLA-4 and its ligand. Anti-Mouse CTLA-4 Antibody (9H10) shows potent anti-tumor effect in various tumor models, such as breast and colon cancer[1][2][3][4].

IC50 & Target

CTLA-4
In Vivo

Anti-Mouse CTLA-4 Antibody (9H10) (200 μg, i.p., at day 15, 18, 21) suppresses tumor growth and metastases companied with radiation in 4T1 tumor mice models[1].
Anti-Mouse CTLA-4 Antibody (9H10) (200 μg, i.p., at day 1, 4, 7) suppresses tumor growth and prolongs survival companied with radiation in 4T1 tumor mice models[2].
Anti-Mouse CTLA-4 Antibody (9H10) (200 μg, i.p., at day 14, 17, 20) inhibits primary and secondary tumor growth companied with radiation in breast and colon cancer mice models[3].
Anti-Mouse CTLA-4 Antibody (9H10) (100 μg for the first time and then two 50 μg-doses at 3-day intervals, i.p.) increases long-term survival rate and shows no experimental allergic encephalomyelitis in astrocytoma mice models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 tumor mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, at day 15, 18, 21, companied with radiation
Result: Inhibited tumors and their metastases.
Reduced CFP+ 4T1 cells.
Demonstrated persistence of highly active immune effector cells.
Reversed migratory and motilityactivity elicited by each monotherapy.
Animal Model: 4T1tumor mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, at day 1, 4, 7, companied with radiation
Result: Significantly delayed the growth of the primary irradiated tumor and prolonged survival of mice.
Animal Model: TSA breast/MCA38 colon cancer mice models[3]
Dosage: 200 μg
Administration: Intraperitoneally injection, at day 14, 17, 20, companied with radiation
Result: Inhibited primary and secondary tumor growth.
Increased tumor-infiltrating lymphocytes.
Animal Model: SMA-560 astrocytoma mice models[4]
Dosage: 100 μg for the first time and then two 50 μg-doses at 3-day intervals
Administration: Intraperitoneally injection
Result: Elicited long-term survival in 80% of mice and no experimental allergic encephalomyelitis.
Restored CD4 numbers in all locations and Treg cells.
Reestablished a normal CD4proliferative capacity.
Enhanced proliferation and Treg resistance on CD4+CD25- T cells but does not alter Treg suppressive function.
Gene ID

12477  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse CTLA-4 Antibody (9H10)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CTLA-4 Antibody (9H10) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CTLA-4 Antibody (9H10)CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152Breast cancerColon cancer4T1AstrocytomaRadiationInhibitorinhibitorinhibit

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