Anti-Mouse CD4 Antibody (GK1.5) 

Anti-Mouse CD4 Antibody (GK1.5) is an anti-mouse CD4 IgG2b monoclonal antibody. Anti-Mouse CD4 Antibody (GK1.5) can significantly deplete CD4⁺ T cells. Anti-Mouse CD4 Antibody (GK1.5) can extend the survival rate of xenograft models. Anti-Mouse CD4 Antibody (GK1.5) can be used for research on immunology. The recommend isotype control of Anti-Mouse CD4 Antibody (GK1.5): Rat IgG2b kappa, Isotype Control (HY-P990682)^[1][2][3].

Rat IgG2b kappa

Rat IgG2b kappa, Isotype Control

CD4

Anti-Mouse CD4 Antibody (GK1.5) (0.2 mg, i.p., single dose, on day 0) increases the proportion of peripheral Treg and reduces the number of thymic Treg in female BALB/c (H-2^d) mice^[1].
Anti-Mouse CD4 Antibody (GK1.5) (on day 4 and 10) can be used to construct a vitiligo mouse model in C57BL/6J mice injected with 2×10⁵ B16F10 melanoma cells^[2].
Anti-Mouse CD4 Antibody (GK1.5) (5 mg/kg, i.p., on day -8 and 6) inhibits tumor metastasis and alters T cell count combined with the OVA peptide vaccine in C57BL/6 mice bearing EG7 tumors^[3].
Anti-Mouse CD4 Antibody (GK1.5) (0.2-5.4 mg, i.p., on day -1, 1, 3, 7 and 10) significantly prolongs the survival time of porcine anterior islet xenografts by depleting CD4⁺ T cells in male CBA/H (H-2^k) mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12504  [NCBI]

NP_038516.1

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD4 Antibody (GK1.5)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yi H, et al. Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence on regulatory CD4+CD25+Foxp3+ T cells in mice. Transplantation. 2008 Apr 27;85(8):1167-74.  [Content Brief]

  [2]. Ni Q, et al. Gut microbiota dysbiosis orchestrates vitiligo-related oxidative stress through the metabolite hippuric acid. Microbiome. 2025 May 6;13(1):112.  [Content Brief]

  [3]. Fujinami N, et al. Enhancement of antitumor effect by peptide vaccine therapy in combination with anti-CD4 antibody: Study in a murine model. Biochem Biophys Rep. 2016 Feb 19;5:482-491.  [Content Brief]

  [4]. Simeonovic CJ, et al. Effect of GK1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD4+ T cell-depleted mice. Transplantation. 1990 May;49(5):849-56.  [Content Brief]