2. Immunology/Inflammation
  3. MHC
  4. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S)

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) 

Cat. No.: HY-P990193 Purity: 95.00%
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Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an anti-mouse MHC Class I (H-2Kd, H-2Dd) IgG2a monoclonal antibody. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the interaction between Ly49 and MHC-I. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can be used for the construction of acute lung injury models.

For research use only. We do not sell to patients.

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S)

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) Chemical Structure

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Description

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an anti-mouse MHC Class I (H-2Kd, H-2Dd) IgG2a monoclonal antibody. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the interaction between Ly49 and MHC-I. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can be used for the construction of acute lung injury models[1][2].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1][2]

MHC I

 

In Vitro

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the binding of Ly49 to MHC-I in splenocytes of mice[2].
Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) (50 μg/well, 1 h) can inhibit TCR mediated T cell proliferation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) Related Antibodies

Cell Proliferation Assay[2]

Cell Line: Splenocytes of OT-I mice
Concentration: 50 μg/well
Incubation Time: 1 h
Result: Inhibited TCR mediated the cell proliferation.
In Vivo

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) (45 mg/kg, i.v., single dose, 18 h after pre stimulation) can successfully induce transfusion-related acute lung injury (TRALI) by combining Lipopolysaccharides (LPS) (HY-D1056) pre-stimulation and CD4+ T cell exhaustion in wild-type male C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type male C57BL/6 mice (8-10 weeks)[1]
Dosage: 45 mg/kg, combined with MHC class I H-2Kb mAb (AF6-88.5.5.3) (4.5 mg/kg)
Administration: Intravenous injection (i.v.), single dose, 18 h after pre stimulation
Result: Caused pulmonary edema in the lungs of mice.
Led to the aggregation of polymorphonuclear neutrophils (PMNs) in the lungs.
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S)MHCMajor Histocompatibility ComplexMHC-ILy49TRALIInhibitorinhibitorinhibit

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