2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. TJU103

TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research.

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TJU103

TJU103 Chemical Structure

CAS No. : 10245-44-0

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TJU103 Related Antibodies

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Description

TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research[1].

Molecular Weight

264.28

Formula

C15H12N4O
CAS No.
SMILES

O=C(C1=CC=NC=C1)N/N=C/C2=CNC3=C2C=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TJU103 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TJU10310245-44-0TJU 103TJU-103Transmembrane GlycoproteinInhibitorCD4T cellsExperimental allergic encephalomyelitisEAE mice modelPLPeSclerosisMSinhibitorinhibit

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