2. Others Vitamin D Related/Nuclear Receptor Epigenetics PI3K/Akt/mTOR
  3. Reference Standards Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor
  4. 4,4'-Sulfonyldiphenol (Standard)

4,4'-Sulfonyldiphenol (Standard)  (Synonyms: Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard))

Cat. No.: HY-W011927R Purity: 99.33%
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4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

For research use only. We do not sell to patients.

4,4'-Sulfonyldiphenol (Standard)

4,4'-Sulfonyldiphenol (Standard) Chemical Structure

CAS No. : 80-09-1

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Information

4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

Molecular Weight

250.27

Formula

C12H10O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(O)C=C1)(C2=CC=C(O)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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4,4'-Sulfonyldiphenol (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4,4'-Sulfonyldiphenol (Standard)80-09-1Bisphenol S (Standard)Bis(4-hydroxyphenyl) sulfone (Standard)Reference StandardsEstrogen Receptor/ERRHistone MethyltransferaseThyroid Hormone ReceptorPI3KAktmTORAndrogen ReceptorTHRPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinEstrogen receptorEndocrine disruptorNipple retentionMammary epitheliumTwo hit modelInhibitorinhibitorinhibit

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