2. Anti-infection
  3. Bacterial
  4. HSGN-94

HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model.

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HSGN-94

HSGN-94 Chemical Structure

CAS No. : 2570797-85-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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HSGN-94 Related Antibodies

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Description

HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model[1].

In Vitro

HSGN-94 (50 μM; 30 min) directly binds to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (PgsA)[1].
HSGN-94 (0.25 μg/mL; 2 h) downregulates the expression level of PgsA, an essential protein for phospholipid synthesis in the bacteria S. aureus[1].
HSGN-94 (16, 32, 64, and 128 μg/mL; 2 h) is not toxic to HaCat cells at concentrations up to 64 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSGN-94 Related Antibodies
In Vivo

HSGN-94 (2%; external use; twice daily for 5 days) decreases MRSA USA300 in infected wounds of mice and results resolution of inflammation in infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA murine wound infection model[1]
Dosage: 2%
Administration: External use; twice daily for 5 days
Result: Reduced the levels of the pro-inflammatory cytokines, monocyte chemo attractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) in MRSA USA300 skin lesions.
Molecular Weight

508.51

Formula

C23H23F3N4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(C=C1)C(NC2=NN=C(O2)C3=CC=C(C=C3)C(F)(F)F)=O)(N4C[C@@H](C[C@@H](C4)C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9665 mL 9.8326 mL 19.6653 mL
5 mM 0.3933 mL 1.9665 mL 3.9331 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9665 mL 9.8326 mL 19.6653 mL 49.1632 mL
5 mM 0.3933 mL 1.9665 mL 3.9331 mL 9.8326 mL
10 mM 0.1967 mL 0.9833 mL 1.9665 mL 4.9163 mL
15 mM 0.1311 mL 0.6555 mL 1.3110 mL 3.2775 mL
20 mM 0.0983 mL 0.4916 mL 0.9833 mL 2.4582 mL
25 mM 0.0787 mL 0.3933 mL 0.7866 mL 1.9665 mL
30 mM 0.0656 mL 0.3278 mL 0.6555 mL 1.6388 mL
40 mM 0.0492 mL 0.2458 mL 0.4916 mL 1.2291 mL
50 mM 0.0393 mL 0.1967 mL 0.3933 mL 0.9833 mL
60 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8194 mL
80 mM 0.0246 mL 0.1229 mL 0.2458 mL 0.6145 mL
100 mM 0.0197 mL 0.0983 mL 0.1967 mL 0.4916 mL
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HSGN-94 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSGN-942570797-85-0HSGN94HSGN 94BacterialInhibitorinhibitorinhibit

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