2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. BAY-1128688

BAY-1128688 is a potent, orally active and selective AKR1C3 inhibitor with IC50 < 2 nM. BAY-1128688 shows high selectivity over related AKR1C enzymes (1C1, 1C2, 1C4) and AKR1D1. BAY-1128688 exhibits no relevant activity at major nuclear hormone receptors. BAY-1128688 reduces endometriotic lesions in the marmoset monkey endometriosis model. BAY-1128688 can be used for endometriosis research.

For research use only. We do not sell to patients.

BAY-1128688

BAY-1128688 Chemical Structure

CAS No. : 1428988-21-9

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BAY-1128688 Related Antibodies

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Description

BAY-1128688 is a potent, orally active and selective AKR1C3 inhibitor with IC50 < 2 nM. BAY-1128688 shows high selectivity over related AKR1C enzymes (1C1, 1C2, 1C4) and AKR1D1. BAY-1128688 exhibits no relevant activity at major nuclear hormone receptors. BAY-1128688 reduces endometriotic lesions in the marmoset monkey endometriosis model. BAY-1128688 can be used for endometriosis research[1].

IC50 & Target[1]

AKR1C3

<2 nM (IC50)

Molecular Weight

462.56

Formula

C28H31FN2O3
CAS No.
SMILES

C[C@@]12[C@](CC=C2C3=CN=CC(F)=C3)([H])[C@@]4([H])[C@@](CC1)([H])C5=CC=C(C(N(C)CCC(O)=O)=O)C=C5CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY-1128688 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-11286881428988-21-9BAY1128688BAY 1128688Aldose ReductaseAKR1C3marmoset monkeyendometriosisInhibitorinhibitorinhibit

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