2. Metabolic Enzyme/Protease JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. Oxidative Phosphorylation STAT Ferroptosis
  4. W1131

W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway.

For research use only. We do not sell to patients.

W1131 Chemical Structure

W1131 Chemical Structure

CAS No. : 2740522-79-4

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Based on 1 publication(s) in Google Scholar

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Description

W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway[1].

Cellular Effect
Cell Line Type Value Description References
AGS IC50
1.28 μM
Compound: 8; W1131
Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36283181]
MGC-803 IC50
0.79 μM
Compound: 8; W1131
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36283181]
In Vitro

W1131 (0-2 μM; 72 h) inhibits cell survival, migration, and invasion in gastric cancer AGS cell, and also inhibits colony formation for 3 days treatment[1].
W1131 (0.1-3 μM; 24 h) potently inhibits the phosphorylation of STAT3 in AGS cells[1].
W1131 (1 μM; 48 h) triggers ferroptosis and suppresses GPX4, SLC7A11, and FTH1 expression in gastric cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

W1131 Related Antibodies

Western Blot Analysis[1]

Cell Line: AGS cells
Concentration: 0.1 μM, 0.3 μM, 1 μM, and 3 μM
Incubation Time: 24 hours
Result: Dose-dependently decreased the phosphorylated Y705-STAT3, but not STAT5, JAK2, and AKT.

Immunofluorescence[1]

Cell Line: AGS cells
Concentration: 0.3 μM, 1 μM
Incubation Time: 12 hours
Result: Significantly promoted lipid ROS formation, and induced Fe2+ accumulation.
In Vivo

W1131 (3 mg/kg, 10 mg/kg; i.p.; once daily for 2 weeks) inhibits tumor growth dose-dependently, and induces ferroptosis in MGC803 subcutaneous xenograft model in BALB/c-nu/nu mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MGC803 subcutaneous xenografts in mouse[1]
Dosage: 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection; once daily for 2 weeks
Result: Inhibited GPX4, SLC7A11, and FTH1 expression level, indicating the induction of ferroptosis.
Caused insignificant change of body weight.
Molecular Weight

429.43

Formula

C23H19N5O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(C3=CN=C4C=C(C5=CCNCC5)C=CN43)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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W1131 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

W11312740522-79-4W 1131W-1131Oxidative PhosphorylationSTATFerroptosisInhibitorinhibitorinhibit

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