2. Apoptosis
  3. Bcl-2 Family
  4. FCN-338

FCN-338 (LOXO-338) is an orally active and selective Bcl-2 inhibitor with an IC50 of 4.5 nM for Bcl-2/BAK interaction. FCN-338 potently inhibits tumor growth in follicular lymphoma (FL), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) xenograft mice model without significant weight loss. FCN-338 has a broad-spectrum anti-cancer activity, such as FL, CLL/SLL, AML, and ALL.

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FCN-338

FCN-338 Chemical Structure

CAS No. : 2248046-39-9

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FCN-338 Related Antibodies

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Description

FCN-338 (LOXO-338) is an orally active and selective Bcl-2 inhibitor with an IC50 of 4.5 nM for Bcl-2/BAK interaction. FCN-338 potently inhibits tumor growth in follicular lymphoma (FL), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) xenograft mice model without significant weight loss. FCN-338 has a broad-spectrum anti-cancer activity, such as FL, CLL/SLL, AML, and ALL[1][2].

IC50 & Targetinhibitor

BCL2

 

Molecular Weight

902.46

Formula

C48H48ClN7O7S
CAS No.
SMILES

ClC1=CC=C(C=C1)C(CC(C)(CC2)C)=C2CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(OC6)=C(C([N+]([O-])=O)=C5)N[C@H]6CC7=CC=CC=C7)=O)=O)C(OC8=CN=C9NC=CC9=C8)=C4)CC3
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Purity & Documentation
References
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FCN-338 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FCN-3382248046-39-9LOXO-338FCN338FCN 338LOXO338LOXO 338Bcl-2 FamilyInhibitorOrally activeBcl-2/BAK interactionSelectiveRS4;11 cellsAnti-cancerFLCLL/SLLAMLand ALLinhibitorinhibit

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