2. GPCR/G Protein Neuronal Signaling MAPK/ERK Pathway
  3. Neurokinin Receptor p38 MAPK
  4. CP-99994

CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.

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CP-99994

CP-99994 Chemical Structure

CAS No. : 136982-36-0

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Other Forms of CP-99994:

CP-99994 Related Antibodies

Top Publications Citing Use of Products

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NK1R NK2R NK3R

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].

IC50 & Target[1]

NK1R

0.25 nM (Ki)

Molecular Weight

296.41

Formula

C19H24N2O
CAS No.
SMILES

COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CP-99994 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-99994136982-36-0CP99994CP 99994Neurokinin Receptorp38 MAPKNK receptorTachykinin receptorAntagonistTachykinin neurokinin 1NK-1 ReceptorColorectal sensitizationNeuroglial interactionsMAPK-p38Bladder-colon cross-sensitization modelInhibitorinhibitorinhibit

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