2. Anti-infection Neuronal Signaling
  3. Bacterial Monoamine Oxidase
  4. MAO-A/B-IN-4

MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections.

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MAO-A/B-IN-4

MAO-A/B-IN-4 Chemical Structure

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MAO-A/B-IN-4 Related Antibodies

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Description

MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections[1].

In Vitro

MAO-A/B-IN-4 (Compound D13) exhibits potent antibacterial activity against S. aureus, MSSA, MRSA, LRSA, and LREFa, with MIC values of < 1 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-A/B-IN-4 Related Antibodies
In Vivo

MAO-A/B-IN-4 (Compound D13) (2.5-40 mg/kg, i.g., 5 min and 6 h post-infection) demonstrates dose-dependent in vivo antibacterial efficacy in ICR mouse model of LRSA peritonitis infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LRSA20-2 bacterial suspension (0.5 mL, 3.5×107 CFU/mL) was intraperitoneally injected into ICR mice to construct the LRSA peritonitis infection model[1]
Dosage: 2.5, 10, 40 mg/kg
Administration: i.g., administration time: 5 min and 6 h post-infection
Result: Achieved survival rates of 0%, 12.5%, and 100% at doses of 2.5, 10, and 40 mg/kg, respectively.
Showed no significant acute toxicity.
Molecular Weight

469.44

Formula

C22H21F2N7O3
SMILES

O=C1O[C@H](CN1C2=CC(F)=C(C(F)=C2)C3=CN=C(C=C3)/C=N/N4CCOCC4)CN5C=CN=N5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-A/B-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-A/B-IN-4BacterialMonoamine OxidaseMAOS. aureusLRSAMAO-A/Bbacterial infectionMSSALREFaInhibitorinhibitorinhibit

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