2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. AA43279

AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model.

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AA43279 Chemical Structure

AA43279 Chemical Structure

CAS No. : 354812-16-1

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Description

AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model[1].

IC50 & Target

Nav1.1

9.5 μM (IC50)

Nav1.6

11.6 μM (IC50)

Nav1.5

14.4 μM (IC50)

Nav1.2

22.8 μM (IC50)

Molecular Weight

248.31

Formula

C12H12N2O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(N)C=C(C2=CC=C(OC)C=C2)S1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (26.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0272 mL 20.1361 mL 40.2722 mL
5 mM 0.8054 mL 4.0272 mL 8.0544 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation

Purity: 99.80%

SDS (393 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0272 mL 20.1361 mL 40.2722 mL 100.6806 mL
5 mM 0.8054 mL 4.0272 mL 8.0544 mL 20.1361 mL
10 mM 0.4027 mL 2.0136 mL 4.0272 mL 10.0681 mL
15 mM 0.2685 mL 1.3424 mL 2.6848 mL 6.7120 mL
20 mM 0.2014 mL 1.0068 mL 2.0136 mL 5.0340 mL
25 mM 0.1611 mL 0.8054 mL 1.6109 mL 4.0272 mL
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AA43279 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AA43279354812-16-1AA 43279AA-43279Sodium ChannelNa channelsNa+ channelsHEK-293anticonvulsantMESTmaximal electroconvulsive seizure threshold testSprague Dawley ratInhibitorinhibitorinhibit

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