STING agonist-45 

STING agonist-45 is a selective STING agonist (EC₅₀ = 0.28 μM). STING agonist-45 activates the innate immune response through the cGAS-STING pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust STING activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6). STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8⁺ T cell infiltration in mouse models. STING agonist-45 is promising for the study of STING-related diseases^[1][2].

STING agonist-45 (Compound 12L) (24 h) induces reporter signal in RAW 264.7 cells with an EC₅₀ value of 5.22 µM ^[1].
STING agonist-45 (24 h) shows obvious cytotoxicity against THP1 cells^[1].
STING agonist-45 (24 h) bind to carboxy terminal domain (CTD) of various hSTING alleles (IC₅₀ = 8.97 µM) and mSTING (IC₅₀ = 4.35 µM)^[1].
STING agonist-45 (Example 1) (24 h) stimulates the production of CXCL10 (IP10) cytokines in THP1 cells, with an EC₅₀ value of 1.6 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-45 (Compound 12L) (3-30 mg/kg, i.v., once a day, 4 days) induces IFN-β protein in C57BL/6 mice model^[1].
STING agonist-45 (10 mg/kg, i.v., once a day, 7 days) reduces tumor volume, prolongs the survival time in B16.F10 tumor-bearing C57BL/6 mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

426.47

C₂₁H₂₆N₆O₄

2361424-97-5

O=C(C1=CC2=C(C(OC3COC3)=C1)N(CCC)C(NC(C4=CC(C)=NN4CC)=O)=N2)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shan B, et al. Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. J Med Chem. 2023 Mar 9;66(5):3327-3347.

  [2]. Jin Li, et al. Immunomodulator, WO2019134707A1.