2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. DNA/RNA Synthesis Cytochrome P450 ROCK
  4. Chloroxoquinoline

Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer.

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Chloroxoquinoline

Chloroxoquinoline Chemical Structure

CAS No. : 23833-97-8

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Chloroxoquinoline Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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ROCK ROCK1 ROCK2

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Description

Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer[1].

Molecular Weight

179.60

Formula

C9H6ClNO
CAS No.
SMILES

O=C1C=CNC2=C1C=CC(Cl)=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Chloroxoquinoline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloroxoquinoline23833-97-8DNA/RNA SynthesisCytochrome P450ROCKCYPsRho-associated protein kinaseRho-associated kinaseRho-kinaseROKDNA templatesRho/Rho kinase signaling pathwayRadiation sensitivityAuto-inductionCYP1ACYP3AAnticancerNSCLCBreast cancerGastric cancerInhibitorinhibitorinhibit

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