2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Ordastobart

Ordastobart  (Synonyms: INBRX-106; ES-102)

Cat. No.: HY-P991336
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Ordastobart (INBRX-106; ES-102) is a hexavalent OX40 agonist antibody. Ordastobart enhances OX40 receptor clustering, signaling, and downstream activation, thereby increasing the proliferation and activation of CD4+ and CD8+ T cells in vitro and in vivo. Ordastobart exhibits anti-tumor effects and improves survival in mouse models of cancer. Ordastobart is indicated for research in cancers such as fibrosarcoma and colorectal cancer.

For research use only. We do not sell to patients.

Ordastobart

Ordastobart Chemical Structure

CAS No. : 2708115-83-5

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Ordastobart Related Antibodies

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Description

Ordastobart (INBRX-106; ES-102) is a hexavalent OX40 agonist antibody. Ordastobart enhances OX40 receptor clustering, signaling, and downstream activation, thereby increasing the proliferation and activation of CD4+ and CD8+ T cells in vitro and in vivo. Ordastobart exhibits anti-tumor effects and improves survival in mouse models of cancer. Ordastobart is indicated for research in cancers such as fibrosarcoma and colorectal cancer[1].

IC50 & Target

TNFRSF4/OX40/CD134
In Vitro

Ordastobart (5-25 nM, 1 h at 37°C) induces high clustering of the OX40 receptor in CHO cells expressing a human OX40 extracellular domain coupled to GFP[1].
Ordastobart (0.001-1000 nM, 96 h) stimulates CD4+ and CD8+ cells enriched from PBMC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ordastobart Related Antibodies

Immunofluorescence[1]

Cell Line: CHO cells expressing a human OX40 extracellular domain coupled to GFP
Concentration: 5, 25 nM
Incubation Time: 1 h at 37°C
Result: Enhanced high-level co-occurrence of GFP (green) and AF647 (magenta) on the cell membrane.

Cell Proliferation Assay[1]

Cell Line: CD4+ and CD8+ T cells enriched from healthy donor peripheral blood mononuclear cells (PBMC)
Concentration: 0.001, 0.01, 0.1, 1, 10, 100, 1000 nM
Incubation Time: 96 h at 37°C
Result: Increaseed human leukocyte antigen (HLA)-DR expression, with maximum activity reaching a peak between 0.1-10 nM and declining at concentrations above 10 nM.
In Vivo

Ordastobart (10  µg/single dose, i.v.) exhibits antitumor activity by inducing robust CD8+ T cell expansion and effector differentiation in MCA-205 or CT26 tumor-bearing mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCA-205 (C57BL/6) or CT26 (BALB/c) tumor-bearing (106) mice (6-8 weeks old, female) model[1]
Dosage: 10  µg/single dose
Administration: i.v.
Result: Demonstrated good tolerability, reduced tumor size, and significantly improved survival.
Engaged and activated CD8+ T cells to control tumor growth.
Expanded CD8+ T cells within tumors and increases T cell frequency and proliferation within LNs; reduces CD8+ T cell frequency in tdLNs but increases proliferation Ki-67.
Increased CD4+ Teff proliferation as compared with controls, enhanced interferon (IFN)-γ and TNF-α production.
Increased the frequency of CD8+ T cells and decreased the frequency of Tregs compared with controls.
CAS No.
SMILES

[Ordastobart]
Storage

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Purity & Documentation
References
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Ordastobart Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ordastobart2708115-83-5INBRX-106 ES-102INBRX106INBRX 106ES102ES 102ES-102Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorAgonistAntibodyMCA-205 cellsCT26 cellsCD4+ cellsCD8+ cellsfibrosarcomacolorectalInhibitorinhibitorinhibit

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