2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. REGN7999

REGN7999 is a monoclonal antibody that inhibits TMPRSS6. REGN7999 inhibits TMPRSS6 activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a β-thalassemia mouse model by inhibiting TMPRSS6 activity. REGN7999 is indicated for research in β-thalassemia.

For research use only. We do not sell to patients.

REGN7999

REGN7999 Chemical Structure

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Description

REGN7999 is a monoclonal antibody that inhibits TMPRSS6. REGN7999 inhibits TMPRSS6 activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a β-thalassemia mouse model by inhibiting TMPRSS6 activity. REGN7999 is indicated for research in β-thalassemia[1][2].

Species Reactivity

Human
IC50 & Target

TMPRSS6
In Vitro

REGN7999 blocks human and mouse TMPRSS6 activity, with IC50s of 0.68, 16 nM, and prevents HJV cleavage in overexpressing HJV and TMPRSS6 HEK293 cells[2].
REGN7999 bounds TMPRSS6 and inhibits TMPRSS6 activity across species, reduces proteolytic activity of human reference and variant TMPRSS6, cynomolgus monkey TMPRSS6, and mouse TMPRSS6[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

REGN7999 Related Antibodies
In Vivo

REGN7999 (10 mg/kg, s.c., once a week, 12 weeks) elevates serum hepcidin, reduces liver iron, restores red blood cell (RBC) levels and improves RBC health in Hbbth3/+ mice model[1][2].
REGN7999 (5 mg/kg, s.c., once) increases serum hepcidin and decreases in serum iron in C57BL/6 mice model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hbbth3/+ mice model[1][2]
Dosage: 10 mg/kg
Administration: s.c., once a week, 12 weeks
Result: Reduced liver iron (~50% reduction compared to the isotype-treated group), improved RBC health as determined by reduced annexin V staining and RBC turnover, extend the RBC life span.
Elevated serum hepcidin and hepatic HAMP1 expression, did not increase markers of liver damage.
Reduced spleen weights to WT levels, displayed normalized reticulocyte numbers, blunted the increase in oxidative stress in blood and spleens, reduced bilirubin levels and lower expression levels of hepatic Hmox1, improved anaerobic capacity, increased bone mineral density.
Animal Model: C57BL/6 mice model[2]
Dosage: 5 mg/kg
Administration: s.c., once
Result: Increased serum hepcidin, and decreased in serum iron, led to a significant drop of transferrin saturation and serum iron in the first 24 hours.
Gene ID

164656  [NCBI]

Accession
Target

TMPRSS6
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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REGN7999 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

REGN7999REGN 7999REGN-7999Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesmonoclonal antibodyβ-thalassemiaHEK293 cellsHbbth3/+ mice modelInhibitorinhibitorinhibit

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