2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Bacterial Reactive Oxygen Species (ROS)
  4. Anti-MRSA agent 33 iodide

Anti-MRSA agent 33 iodide is an anti-Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) agent, with MIC values of 2-4 μg/mL. Anti-MRSA agent 33 iodide demonstrates effective biofilm eradication and minimal cytotoxicity toward mammalian cells. Anti-MRSA agent 33 iodide specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death. Anti-MRSA agent 33 iodide reduces bacterial load in a murine skin infection model.

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Anti-MRSA agent 33 iodide

Anti-MRSA agent 33 iodide Chemical Structure

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Anti-MRSA agent 33 iodide Related Antibodies

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Description

Anti-MRSA agent 33 iodide is an anti-Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) agent, with MIC values of 2-4 μg/mL. Anti-MRSA agent 33 iodide demonstrates effective biofilm eradication and minimal cytotoxicity toward mammalian cells. Anti-MRSA agent 33 iodide specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death. Anti-MRSA agent 33 iodide reduces bacterial load in a murine skin infection model[1].

In Vitro

Anti-MRSA agent 33 iodide (Compound IV4) (16-20 h) shows antibacterial activity against S. aureus ATCC 29213, MRSA N315, 10 clinical MRSA isolates (M22, M17, M16, M23, M14, M13, M11, M21, M12 and M20), with MIC values of 2-4 μg/mL[1].
Anti-MRSA agent 33 iodide (8-32 μg/mL, 3-6 h) combines rapid bactericidal activity against S. aureus ATCC 29213 and MRSA N315, with low resistance induction potential[1].
Anti-MRSA agent 33 iodide (2-16 μg/mL, 3-6 h) has the effect of disrupting bacterial biofilms (S. aureus ATCC 29213 and MRSA N315)[1].
Anti-MRSA agent 33 iodide (2-128 μg/mL) demonstrates superior safety profiles with IC50 values of 22.48 and 27.45 μg/mL for RAW 264.7 and NIH 3T3 cells, respectively[1].
Anti-MRSA agent 33 iodide (4-64 μg/mL) specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 33 iodide Related Antibodies

Apoptosis Analysis[1]

Cell Line: MRSA N315
Concentration: 4, 8, 16, 32, 64 μg/mL
Incubation Time: 4 h
Result: Showed complete membrane destruction and bacterial death.

Real Time qPCR[1]

Cell Line: MRSA N315
Concentration: 8 μg/mL
Incubation Time: 2 h
Result: Inhibited the expression of amaP, qoxA, qoxB, and atpB.
Upregulated the levels of ahpC.
In Vivo

Anti-MRSA agent 33 iodide (Compound IV4) (5-10 mg/kg, subcutaneously administered, single dose) reduces bacterial load and attenuates inflammation without systemic toxicity in a murine skin infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM mice aged 6-8 weeks were subcutaneously inoculated with MRSA suspension (6 × 108 cfu/mL)[1]
Dosage: 5, 10 mg/kg
Administration: Subcutaneously administered for a single dose after MRSA suspension 4 h
Result: Showed smooth skin surface at the infection site and prevented obvious inflammatory cell infiltration in both the epidermis and dermis.
Reduced IL-6 and TNF-α levels.
Showed no pathological changes (inflammation/necrosis/hemorrhage) in the heart, lungs, spleen, or kidneys, with normal tissue architecture and cell arrangement.
Molecular Weight

682.60

Formula

C35H35IN6O
SMILES

C[N+](CCCCN1C2=CC=CC=C2C3=C1C4=NC5=C(C(N4CC3)=O)C=CC=C5)(CC6=NC=CC=C6)CC7=CC=CC=N7.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-MRSA agent 33 iodide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MRSA agent 33BacterialReactive Oxygen Species (ROS)phosphatidylglycerolROSStaphylococcus aureusBacteriaInhibitorinhibitorinhibit

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