2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP7-IN-17

PARP7-IN-17 is a potent inhibitor of PARP7 with IC50 of 4.5 nM that has oral bioavailability. PARP7-IN-17 displays antitumor effect.

For research use only. We do not sell to patients.

PARP7-IN-17 Chemical Structure

PARP7-IN-17 Chemical Structure

CAS No. : 3024030-10-9

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Based on 1 publication(s) in Google Scholar

PARP7-IN-17 Related Antibodies

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Description

PARP7-IN-17 is a potent inhibitor of PARP7 with IC50 of 4.5 nM that has oral bioavailability. PARP7-IN-17 displays antitumor effect[1].

IC50 & Target

PARP7

 

Molecular Weight

447.41

Formula

C20H20F3N7O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC2=CN(N=C21)[C@@H](C)C(N3CCN(CC3)C4=NC=C(C=N4)C(F)(F)F)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2351 mL 11.1754 mL 22.3509 mL
5 mM 0.4470 mL 2.2351 mL 4.4702 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2351 mL 11.1754 mL 22.3509 mL 55.8772 mL
5 mM 0.4470 mL 2.2351 mL 4.4702 mL 11.1754 mL
10 mM 0.2235 mL 1.1175 mL 2.2351 mL 5.5877 mL
15 mM 0.1490 mL 0.7450 mL 1.4901 mL 3.7251 mL
20 mM 0.1118 mL 0.5588 mL 1.1175 mL 2.7939 mL
25 mM 0.0894 mL 0.4470 mL 0.8940 mL 2.2351 mL
30 mM 0.0745 mL 0.3725 mL 0.7450 mL 1.8626 mL
40 mM 0.0559 mL 0.2794 mL 0.5588 mL 1.3969 mL
50 mM 0.0447 mL 0.2235 mL 0.4470 mL 1.1175 mL
60 mM 0.0373 mL 0.1863 mL 0.3725 mL 0.9313 mL
80 mM 0.0279 mL 0.1397 mL 0.2794 mL 0.6985 mL
100 mM 0.0224 mL 0.1118 mL 0.2235 mL 0.5588 mL
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PARP7-IN-17 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP7-IN-173024030-10-9PARPpoly ADP ribose polymerasetumor microenvironmentCT26 syngeneic mouse modelInhibitorinhibitorinhibit

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