2. GPCR/G Protein Stem Cell/Wnt
  3. LPL Receptor Wnt
  4. GSK3178022

GSK3178022 is a human IgG1 monoclonal antibody (mAb) targeting LRP6. GSK3178022 inhibits the expression of WNT target genes SP5 and AXIN2. GSK3178022 has antitumor activity in the RSPO fusion model of colorectal cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

GSK3178022 Chemical Structure

GSK3178022 Chemical Structure

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GSK3178022 Related Antibodies

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Description

GSK3178022 is a human IgG1 monoclonal antibody (mAb) targeting LRP6. GSK3178022 inhibits the expression of WNT target genes SP5 and AXIN2. GSK3178022 has antitumor activity in the RSPO fusion model of colorectal cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
IC50 & Target

SP5 & AXIN2
Gene ID

389058  [NCBI] & 8313  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[GSK3178022]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK3178022 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3178022GSK 3178022GSK-3178022LPL ReceptorWntLysophospholipid ReceptorWNTcolorectal cancerPA-1HT-1080NTERA-2Inhibitorinhibitorinhibit

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